Descriptive epidemiology and outcomes of bone sarcomas in adolescent and young adult patients in Japan

Table 1 Characteristics of bone sarcomas in AYAs by age at diagnosis and relevant clinical factor

	Overall		AYA		Child		Adult		Elderly		P value
	Overall		(15-39 years)		(−14 years)		(40-64 years)		(65- years)		P value
	N	%	N	%	N	%	N	%	N	%
Total	3457		1123	32.5%	521	15.1%	982	28.4%	831	24.0%
Histologic subtype											< 0.001
Osteosarcoma	1497	43.3%	631	56.2%	405	77.7%	278	28.3%	183	22.0%
Chondrosarcoma	885	25.6%	198	17.6%	8	1.5%	376	38.3%	303	36.5%
Ewing’s sarcoma	260	7.5%	139	12.4%	92	17.7%	28	2.9%	1	0.1%
Bone MFH	205	5.9%	22	2.0%	2	0.4%	82	8.4%	99	11.9%
Chordoma	253	7.3%	16	1.4%	2	0.4%	88	9.0%	147	17.7%
HG sarcoma(others)	214	6.2%	52	4.6%	4	0.8%	85	8.7%	73	8.8%
LG sarcoma(others)	143	4.1%	65	5.8%	8	1.5%	45	4.6%	25	3.0%
Sex											0.028
Male	1930	55.8%	656	58.4%	278	53.4%	561	57.1%	435	52.3%
Female	1527	44.2%	467	41.6%	243	46.6%	421	42.9%	396	47.7%
Tumor size (cm), mean [SD]	9.1 [4.9]		8.8 [4.5]		10.3 [4.8]		8.9 [5.1]		9.0 [5.1]		< 0.001
≤8 cm	1655	47.9%	538	47.9%	193	37.0%	510	51.9%	414	49.8%
> 8 cm and ≤ 16 cm	1299	37.6%	432	38.5%	246	47.2%	322	32.8%	299	36.0%
> 16 cm	243	7.0%	61	5.4%	50	9.6%	67	6.8%	65	7.8%
Unknown	260	7.5%	92	8.2%	32	6.1%	83	8.5%	53	6.4%
Tumor location											< 0.001
Upper extremity	349	10.1%	134	11.9%	40	7.7%	105	10.7%	70	8.4%
Lower extremity	1689	48.9%	629	56.0%	395	75.8%	399	40.6%	266	32.0%
Trunk	1276	36.9%	303	27.0%	72	13.8%	437	44.5%	464	55.8%
Head and neck	35	1.0%	18	1.6%	2	0.4%	10	1.0%	5	0.6%
Multiple disease	108	3.1%	39	3.5%	12	2.3%	31	3.2%	26	3.1%
Surgery	2473	71.5%	868	77.3%	430	82.5%	713	72.6%	462	55.6%	< 0.001
Chemotherapy	1765	51.1%	769	68.5%	474	91.0%	374	38.1%	148	17.8%	< 0.001
Radiotherapy	724	20.9%	188	16.7%	81	15.5%	206	21.0%	249	30.0%	< 0.001

SD standard deviation, AYA adolescent and young adult, MFH malignant fibrous histiocytoma, HG sarcoma High grade sarcoma, LG sarcoma Low grade sarcoma

ISSN: 1471-2474