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Table 1 Characteristics of bone sarcomas in AYAs by age at diagnosis and relevant clinical factor

From: Descriptive epidemiology and outcomes of bone sarcomas in adolescent and young adult patients in Japan

  Overall AYA Child Adult Elderly P value
(15-39 years) (−14 years) (40-64 years) (65- years)
N % N % N % N % N %  
Total 3457   1123 32.5% 521 15.1% 982 28.4% 831 24.0%  
Histologic subtype            < 0.001
 Osteosarcoma 1497 43.3% 631 56.2% 405 77.7% 278 28.3% 183 22.0%  
 Chondrosarcoma 885 25.6% 198 17.6% 8 1.5% 376 38.3% 303 36.5%  
 Ewing’s sarcoma 260 7.5% 139 12.4% 92 17.7% 28 2.9% 1 0.1%  
 Bone MFH 205 5.9% 22 2.0% 2 0.4% 82 8.4% 99 11.9%  
 Chordoma 253 7.3% 16 1.4% 2 0.4% 88 9.0% 147 17.7%  
 HG sarcoma(others) 214 6.2% 52 4.6% 4 0.8% 85 8.7% 73 8.8%  
 LG sarcoma(others) 143 4.1% 65 5.8% 8 1.5% 45 4.6% 25 3.0%  
Sex            0.028
 Male 1930 55.8% 656 58.4% 278 53.4% 561 57.1% 435 52.3%  
 Female 1527 44.2% 467 41.6% 243 46.6% 421 42.9% 396 47.7%  
Tumor size (cm), mean [SD] 9.1 [4.9] 8.8 [4.5] 10.3 [4.8] 8.9 [5.1] 9.0 [5.1] < 0.001
 ≤8 cm 1655 47.9% 538 47.9% 193 37.0% 510 51.9% 414 49.8%  
 > 8 cm and ≤ 16 cm 1299 37.6% 432 38.5% 246 47.2% 322 32.8% 299 36.0%  
 > 16 cm 243 7.0% 61 5.4% 50 9.6% 67 6.8% 65 7.8%  
 Unknown 260 7.5% 92 8.2% 32 6.1% 83 8.5% 53 6.4%  
Tumor location            < 0.001
 Upper extremity 349 10.1% 134 11.9% 40 7.7% 105 10.7% 70 8.4%  
 Lower extremity 1689 48.9% 629 56.0% 395 75.8% 399 40.6% 266 32.0%  
 Trunk 1276 36.9% 303 27.0% 72 13.8% 437 44.5% 464 55.8%  
 Head and neck 35 1.0% 18 1.6% 2 0.4% 10 1.0% 5 0.6%  
 Multiple disease 108 3.1% 39 3.5% 12 2.3% 31 3.2% 26 3.1%  
Surgery 2473 71.5% 868 77.3% 430 82.5% 713 72.6% 462 55.6% < 0.001
Chemotherapy 1765 51.1% 769 68.5% 474 91.0% 374 38.1% 148 17.8% < 0.001
Radiotherapy 724 20.9% 188 16.7% 81 15.5% 206 21.0% 249 30.0% < 0.001
  1. SD standard deviation, AYA adolescent and young adult, MFH malignant fibrous histiocytoma, HG sarcoma High grade sarcoma, LG sarcoma Low grade sarcoma