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Table 2 Summary of included study characteristics

From: Efficacy of extracorporeal shock wave therapy for knee tendinopathies and other soft tissue disorders: a meta-analysis of randomized controlled trials

Study author (year) [reference]

Groups

Age (years)

Mean (SD)

Sex F/M

N

Design

Diagnosis

Involved side Unilateral/bilateral

Athlete/nonathlete

Duration of symptoms (months)

Mean (SD, range)

Cointervention

Follow up time point

Outcome results

Fund or grant§

MQ score*

Chen (2014) [51]

EG: ESWT + MSE

63.0 (7.4)‡

102/18‡

30

RCT, DB

Popliteal cyamella

NR

Nonathlete

10–144‡

None

Baseline

VASb,c; ROMb,c

Funded

7/10

CG 1: USD + MSE

  

30

      

Posttest: ≤1, 6 months

Lequesne’s indexb,c

  

CG 2: MSE

  

30

          

CG 3: Non-ESWT†

  

30

          

Geng (2017) [90]

EG: ESWT + APT

35.9 (10.2)‡

19/41‡

30

RCT

CPT

NR

Nonathlete

4.7 (2.8) ‡

None

Baseline

VASa,b,c; PTTa,b,c

Funded

6/10

CG: CT

  

30

      

Posttest: 1 month

4-point Likert scalec

  

Guan (2015) [80]

EG: ESWT

45.5 (20–80)‡

91/55‡

73

RCT

PAT

128/18‡

Nonathlete

12.5 (6–36)‡

None

Baseline

VASa,b,c

NR

6/10

CG: CT

  

73

      

Posttest: 6 months

   

Huang (2017) [88]

EG: ESWT

22.0 (3.0)

0/31

31

RCT

CPT

28/3

Athlete

12.0 (6–24)

None

Baseline

VASa,b,c; VISA-Pa,b,c

Funded

6/10

CG: CT

21.0 (3.0)

0/30

30

  

29/1

 

11.0 (6–20)

 

Posttest: 1, 3, 12 months

4-point Likert scalec

  

Jiang (2016) [81]

EG: ESWT

35.7 (9.1)

24/16

40

RCT

CPT

40/0

Nonathlete

4.2 (3.9)

PT

Baseline

VASa,b,c; PIb,c

NR

6/10

CG: Non-ESWT†

34.4 (10.7)

21/15

36

  

36/0

 

4.7 (4.4)

Pain medication

Posttest: ≤1, 2 weeks

KOS-ADLSa,b,c

  

Khosrawi (2017) [48]

EG: ESWT

49.4 (7.8)

16/4

20

RCT, SB

PAT

NR

Nonathlete

> 3 months‡

STE

Baseline

VASa,b,c; MPQa,b,c

Funded

8/10

CG: Sham ESWT

50.2 (8.1)

15/5

20

     

Pain medication

Posttest: ≤1, 2 months

   

Liu (2016) [82]

EG: ESWT

22.1 (1.5)

22/28

50

RCT, SB

CPT

50/0

Athlete

4.9 (1.3, 3–6)

APT

Baseline

VASa,b,c; VISA-Pa,b,c

Funded

6/10

CG: Iontophoresis

22.2 (1.3)

23/27

50

  

50/0

 

5.0 (1.1, 3–6)

Massage

Posttest: ≤1, 3, 6, 12 months

4-point RMSc

  

Taunton (2003) [83]

EG: ESWT

23–52‡

5/5

10

RCT, SB

CPT

NR

Athlete

> 3 months ‡

None

Baseline

VISA-Pa,b,c

Funded

5/10

CG: Sham ESWT

 

5/5

10

      

Posttest: ≤1, 3 months

Vertical jump testb,c

  

Thijs (2017) [84]

EG: ESWT

30.5 (8.0)

8/14

22

RCT, DB

CPT

NR

Nonathlete

16.3 (18.2, 3–78)

ET exercise

Baseline

VASa,b; VISA-Pa,b

NR

9/10

CG: Sham ESWT

27.3 (5.2)

6/24

30

    

24.9 (31.6, 3–125)

 

Posttest: ≤1, 3, 6 months

6-point Likert scale

  

Vetrano (2013) [85]

EG: ESWT

26.8 (8.5)

6/17

23

RCT, SB

CPT

23/0

Athlete

17.6 (20.2)

STE

Baseline

VASa,b,c; VISA-Pa,b,c

NR

7/10

CG: PRP

26.9 (9.1)

3/20

23

  

23/0

 

18.9 (19.1)

 

Posttest: 2, 6, 12 months

MBSa,b,c

  

Wang (2014) [86]

EG: ESWT

28.3 (7.4)

5/21

26

RCT, SB

ACL reconstruction

26/0

Nonathlete

21.4 (22.5, 1–72)

PT

Baseline

LFSa,b,c

Funded

8/10

CG: Non-ESWT†

27.7 (7.7)

6/21

27

  

27/0

 

15.4 (21.9, 1–84)

 

Posttest: 12, 24 months

IKDC scorea,b

  

Weckström (2016) [52]

EG: ESWT

23.7 (2.0)

6/14

11

RCT

ITBS

NR

Nonathlete

60.4 (53.7)

MSE

Baseline

11-point NRSb;

NR

7/10

CG: CT

24.2 (2.2)

7/13

13

    

42.3 (65.1)

STE

Posttest: 1, 2, 12 months

Treadmill test

  

Wu (2009) [91]

EG: ESWT

15.9 (11–19)

9/21

30

RCT

OSD

NR

Athlete

3–36

None

Baseline

VASa,b,c; MPQa,b,c

NR

6/10

CG: USD

16.5 (14.–19)

7/23

30

    

3–36

 

Posttest: 0, 3 months

3-point Likert scalec

  

Wu (2016) [89]

EG: ESWT

26.0 (19–38)‡

7/55‡

31

RCT

ACL injury

31/0

Nonathlete

3.8 (1–12)‡

PT

Baseline

VASa,b,c

NR

6/10

CG: Non-ESWT†

  

31

  

31/0

   

Posttest: ≤1 month

4-point Likert scalec

  

Yang (2007) [16]

EG: ESWT

34.0 (7.4)

6/22

28

RCT

PTKS

28/0

Nonathlete

6.0 (5.3)

MSE

Baseline

VASa,b,c; ROMa,b,c

NR

5/10

CG: CPM

33.0 (8.4)

9/20

29

  

29/0

 

6.0 (3.3)

 

Posttest: ≤1 month

4-point Likert scalec

  

Zhang (2016) [92]

EG: ESWT

48.0 (4.6)

10/8

18

RCT, SB

Traumatic synovitis

18/0

Nonathlete

1–2

APT; MSE

Baseline

VASa,b,c; ROMa,b,c;

Funded

6/10

CG: Non-ESWT†

50.0 (5.8)

11/7

18

  

18/0

 

1–2

 

Posttest: 2, 4, 6 weeks

Swellinga,b,c; LFSa,b,c 4-point Likert scale

  

Zhang (2017) [17]

EG: ESWT

34.8 (5.6)

7/21

28

RCT

PTKS

28/0

Nonathlete

4.7 (2.3)

PT

Baseline

VASa,b,c; ROMa,b,c;

NR

6/10

CG: Non-ESWT†

35.5 (4.9)

9/17

26

  

26/0

 

4.3 (2.6)

 

Posttest: 0 month

HSSa,b,c; 4-point Likert scale

  

Zhou (2015) [53]

EG: ESWT

25.0 (18–30)‡

30/30‡

30

RCT

IPFP injury

50/10

Athlete

24 (1–48)‡

None

Baseline

VASa,b,c;

NR

6/10

CG: APT

  

30

      

Posttest: ≤1 month

4-point Likert scalec

  

Zwerver (2011) [87]

EG: ESWT

24.2 (5.2)

11/20

31

RCT, DB

CPT

18/13

Athlete

7.3 (3.6)

Sports participation

Baseline

VAS a,b; VISA-P a,b;

Funded

9/10

CG: Sham ESWT

25.7 (4.5)

10/21

31

  

13/18

 

8.1 (3.8)

Medical treatment

Posttest: ≤1, 3, 6 months

Knee-loading pain test

  
  1. *Assessed using the 10-point PEDro classification scale
  2. †No application of shock wave treatment
  3. ‡Value of total sample
  4. §Details of the funding information of the studies are presented in Additional file 10: Table S3
  5. aSignificant improvements in the control group compared with baseline (P < 0.05)
  6. bSignificant improvements in the experimental group compared with baseline (P < 0.05)
  7. cSignificant between-group difference for ESWT compared with control (P < 0.05)
  8. MQ methodological quality, EG experimental group, CG control group, ESWT extracorporeal shock wave therapy, RCT randomized controlled trial, QRCT Quasi-randomized controlled trial, DB double blind, VAS visual analog scale, NR not reported, ET eccentric training, VISA-P Victorian Institute of Sport Assessment-Patella, PRP platelet-rich plasma, PTKS posttraumatic knee stiffness, USD ultrasound diathermy, MSE muscular strengthening exercise, APT acupuncture therapy, LPNIR-LI linear polarized near-infrared light irradiation, CT conservative treatment, STE stretching exercise, ITBS iliotibial band syndrome, OSD Osgood–Schlatter disease, CPT chronic patellar tendinopathy, PTT patellar tendon thickness, PT physiotherapy, PAT pes anserine tendinopathy, MPQ McGill pain questionnaire, PI patellar intumesce, KOS-ADLS Knee Outcome Survey-activities of Daily Living Scale, ACL anterior cruciate ligament, LFS Lysholm functional score, MBS Modified Blazina scale, IKDC International Knee Documentation Committee, CPM continuous passive motion, LCSI local corticosteroid injection, HSS Hospital for Special Surgery Knee score, IPFP infrapatellar fat pad, ROM range of motion