Table 1 Schedule of assessments

Informed consent

x

Clinical examination

x

Knee x-ray

x

Bloods

x

x*

Knee MRI

x

x

x

Randomisation

x

 Leg strength

x

x

x

x

 Height and weight

x

x

x

 First void fasting urine

x*

x*

 Infusion

x

x

 Demographics (sex, date of birth)

x

 Knee VAS

x

x

x

x

x

x

x

 Knee WOMAC

x

x

x

x

x

x

 Medication use

x

x

x

x

x

x

 Knee surgery

x

x

x

x

x

x

 Knee joint injection

x

x

x

x

 Safety (adverse events)

x

x

x

x

x

x

x

x

 Acute phase reactions

x

x

 Hand VAS

x

x

x

x

x

x

 Back VAS

x

x

x

x

x

x

 AQoL-4D

x

x

x

 Overall change in pain and function

x

 Treatment guessing

x