BMC Musculoskeletal Disorders

Table 3 GRADE evidence profile of RCTs for effect of BPs on periprosthetic bone loss after TKA

From: Effect of bisphosphonates on periprosthetic bone loss after total knee arthroplasty: a meta-analysis of randomized controlled trials

	Summary of findings			Quality assessment
	Time points	n (treated/control)	WMD (95%CI, g/cm²)	Limitations	Inconsistency	Indirectness	Imprecision	Others	Quality
Tibia	3 months	2 (48/50)	0.07 (0.04–0.10)	No serious^a	No serious^b	No serious	Serious^c	Strong association^d	Moderate
	6 months	3 (78/80)	0.12 (0.10–0.15)	No serious	No serious	No serious	No serious	Strong association^d	High
	12 months	3 (77/75)	0.12 (0.10–0.15)	No serious	Serious	No serious	No serious	None	Moderate
Femur	3 months	3 (56/61)	0.07 (0.04–0.10)	No serious	No serious	No serious	Serious	Strong association	Moderate
	6 months	5 (91/97)	0.12 (0.10–0.15)	No serious	Serious	No serious	No serious	Strong association	Moderate
	12 months	4 (85/86)	0.12 (0.10–0.15)	No serious	Serious	No serious	No serious	Strong association	Moderate

^aThe inadequate blinding and substantial loss follow-up in some trials may raise risk of bias
^bInconsistent report of outcomes and significant heterogeneity existed across the trials
^cThe number of included patients less than 150 is considered to be small and may cause imprecision
^dEffect size more than 0.05 is considered to be large and strengthen the evidence

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ISSN: 1471-2474

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