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Fig. 7 | BMC Musculoskeletal Disorders

Fig. 7

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Fig. 7

a Profile of diclofenac sodium (DF) concentrations in the synovium after a single IA administration of SI-613 in rabbits with antigen-induced arthritis. SI-613 was intra-articularly injected at a dose of 5 mg/joint, and each value shows the mean ± standard deviation (S.D.) of 3 animals. The lower limit of quantification was 5 ng/g. b Profile of DF concentrations in the joint cavity after a single IA administration of SI-613 in rabbits with antigen-induced arthritis. SI-613 was intra-articularly injected at a dose of 5 mg/joint, and each value shows the mean ± S.D. of 3 animals. The lower limit of quantification was 1 ng of DF per mL of synovial lavage fluid

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