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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Fig. 2

Analgesic effect of SI-613 in silver nitrate-induced arthritic pain model in rats. Silver nitrate-induced arthritic rats given 0.05 mg (closed circle), 0.15 mg (closed triangle), 0.5 mg (closed square) SI-613, or vehicle (open circle) intra-articularly, and non-treated normal rats (open square) were evaluated for pain score (a) and weight-bearing rate (b) over time. Mean values of pain scores (c) and weight-bearing rate (d) for 3 days were calculated and subjected to statistical analysis: two-way analyses of variance followed by Williams’ test. ***p < 0.005, **p < 0.01, *p < 0.05 (vs. control, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals (n = 9 per group, except for the normal group n = 3)

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