Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: a meta-analysis

Table 1 Main characteristics of included studies

Study	Country	Ethnicity	Sample size	Source of patients	Diagnostic criteria	Case			Control			HWE
rs35767						CC	CT	TT	CC	CT	TT
Fan, 2017	China	Chinese	346/346	Both gender	WHO	154	163	29	152	157	37	0.932
Li, 2014	China	Chinese	216/220	PMOP women	WHO	95	94	27	114	89	17	0.998
Li, 2015	China	Chinese	485/485	PMOP women	WHO	202	210	74	238	201	46	0.932
Liu, 2017	China	Chinese	320/320	Both gender	WHO	152	136	32	156	131	33	0.781
Wei, 2015	China	Chinese	272/272	PMOP women	WHO	124	118	30	132	116	24	0.979
Zhang, 2015	China	Chinese	428/428	Both gender	WHO	182	193	53	216	186	26	0.233
rs2288377						AA	AT	TT	AA	AT	TT
Fan, 2017	China	Chinese	346/346	Both gender	WHO	118	171	57	164	160	22	0.113
Li, 2014	China	Chinese	216/220	PMOP women	WHO	182	21	13	189	21	10	< 0.001
Li, 2015	China	Chinese	485/485	PMOP women	WHO	396	52	36	413	45	27	< 0.001
Liu, 2017	China	Chinese	320/320	Both gender	WHO	125	145	50	157	138	25	0.781
Zhang, 2015	China	Chinese	428/428	Both gender	WHO	349	44	35	365	40	23	< 0.001
rs5742612
Fan, 2017	China	Chinese	346/346	Both gender	WHO	298	30	18	301	35	10	< 0.001
Li, 2014	China	Chinese	216/220	PMOP women	WHO	178	21	17	183	21	16	< 0.001
Li, 2015	China	Chinese	485/485	PMOP women	WHO	389	55	41	400	50	35	< 0.001
Liu, 2017	China	Chinese	320/320	Both gender	WHO	264	33	23	245	69	6	0.907
Zhang, 2015	China	Chinese	428/428	Both gender	WHO	336	48	44	346	42	41	< 0.001

PMOP: post-menopausal; WHO: World Health Organization criteria; HWE: Hardy-Weinberg Equilibrium
Statistically significant findings appeared in bold

ISSN: 1471-2474