Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

Huang, Donghua; Xiao, Jinrong; Deng, Xiangyu; Ma, Kaige; Liang, Hang; Shi, Deyao; Wu, Fashuai; Shao, Zengwu

doi:10.1186/s12891-018-2057-z

BMC Musculoskeletal Disorders

Table 2 Distribution of genotypes among cases and controls

From: Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

	Study ID	Year	Diagnosis	Ethnicity	Case Group			Control Group			P_HWE
FAS (CD95) site
-670 G > A rs1800682					GG	GA	AA	GG	GA	AA
	Lv et al. [32]	2009	IVDD	Chinese	47	125	51	21	67	36	0.28
	Zhu et al. [24]	2011	IVDD	Chinese	57	162	129	30	96	89	0.62
	Sun et al. [19]	2013	IVDD	Chinese	74	217	181	61	265	202	0.06
	Zhang et al. [23]	2013	IVDD	Chinese	20	59	49	14	68	50	0.19
	Sezgin et al. [22]	2013	OA	Caucasoid	27	63	58	21	46	35	0.41
	Coakley et al. [25]	1999	RA	Caucasoid	4	8	6	31	61	36	0.61
	Huang et al. [26]	1999	RA	Caucasoid	32	105	48	22	44	20	0.83
	Lee et al. [28]	2001	RA	Korean	16	38	33	13	48	26	0.23
	Mohammadzadeh et al. [29]	2012	RA	Caucasoid	17	64	39	18	50	44	0.55
	Kobak et al. [27]	2012	RA	N/D	24	50	27	14	52	39	0.61
	Seyfi et al. [30]	2013	RA	Caucasoid	20	45	35	22	40	39	0.06
−1377 G > A rs2234767					GG	GA	AA	GG	GA	AA
	Zhu et al. [24]	2011	IVDD	Chinese	121	172	55	99	92	24	0.71
	Sun et al. [19]	2013	IVDD	Chinese	218	209	45	236	248	44	0.06
	Zhang et al. [23]	2013	IVDD	Chinese	59	55	14	56	65	11	0.19
	Sezgin et al. [22]	2013	OA	Caucasoid	95	51	2	42	60	0	< 0.01
	Seyfi et al. [30]	2013	RA	Caucasoid	74	26	0	81	18	2	0.41
	Zhu et al. [31]	2016	RA	Chinese	246	284	68	389	357	85	0.82
FASL (CD178) site
IVS2nt-124 A > G rs5030772					GG	GA	AA	GG	GA	AA
	Sezgin et al. [22]	2013	OA	Caucasoid	4	37	107	4	30	68	0.76
	Mohammadzadeh et al. [29]	2012	RA	Caucasoid	8	35	77	6	31	75	0.25
	Seyfi et al. [30]	2013	RA	Caucasoid	6	25	68	10	29	60	0.03
−844 T > C rs763110					CC	CT	TT	CC	CT	TT
	Zhu et al. [24]	2011	IVDD	Chinese	175	148	25	131	76	8	0.46
	Sun et al. [19]	2013	IVDD	Chinese	236	188	48	308	200	20	0.07
	Zhang et al. [23]	2013	IVDD	Chinese	64	51	13	77	50	5	0.37
	Sezgin et al. [22]	2013	OA	Caucasoid	45	80	23	37	47	18	0.65
	Mohammadzadeh et al. [29]	2012	RA	Caucasoid	33	63	24	43	49	20	0.36
	Kobak et al. [27]	2012	RA	N/D	30	40	31	33	40	23	0.12
	Seyfi et al. [30]	2013	RA	Caucasoid	20	55	25	31	54	14	0.22
	Zhu et al. [31]	2016	RA	Chinese	331	228	34	453	317	51	0.65

Abbreviations: HWE Hardy–Weinberg equilibrium

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