Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway

Table 3 Genotypic and allelic distribution of four SNP loci in the exon regions of BMPR-IA gene between OPLL patients and non-OPLL Controls

SNPs	-349C > T			4A > C			1327C > T			1395G > C
SNPs	exon1			exon3, Pro2Thr			exon11, Arg443Cys			exon12, Pro465Pro
Genotype	CC	CT	TT	AA	AC	CC	CC	CT	TT	GG	GC	CC
OPLL (n = 356)	83	190	83	145	143	68	206	85	65	120	156	80
Control (n = 617)	297	246	74	283	284	50	370	148	99	240	222	155
Pearson Chi-Square Test	P < 0.001			P < 0.001			P = 0.662			P = 0.436
Allele	C	T		A	C		C	T		G	C
OPLL	356	356		433	279		497	215		396	316
Control	840	394		850	384		888	346		702	532
Pearson Chi-Square Test	P < 0.001			P < 0.001			P = 0.311			P = 0.586

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