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Table 3 Meta-analysis of disc degeneration grades among IDD patients with different TRAIL 1595C/T genotypes and alleles

From: TRAIL gene 1595C/T polymorphisms contribute to the susceptibility and severity of intervertebral disc degeneration: a data synthesis

Author Genotypes or alleles n Grade II Grade III Grade IV χ2 or Z value a P value
Zhang [10] CC 192 94 (48.96%) 42 (21.88%) 56 (29.17%)   
CT 79 48 (60.76%) 22 (27.85%) 9 (11.39%)   
TT 41 20 (48.78%) 15 (36.59%) 6 (14.63%) 175.400 <0.001
C 463 236 (50.97%) 106 (22.89%) 121 (26.13%)   
T 161 88 (54.66%) 52 (32.30%) 21 (13.04%) −19.612 <0.001
Du [8] CC 46 14 (30.43%) 12 (26.09%) 20 (43.48%)   
CT 71 22 (30.99%) 18 (25.35%) 31 (43.66%)   
TT 36 20 (55.56%) 9 (25.00%) 7 (19.44%) 66.501 <0.001
C 163 50 (30.67%) 42 (25.77%) 71 (43.56%)   
T 143 62 (43.36%) 36 (25.17%) 45 (31.47%) −5.346 <0.001
Xu [9] CC 37 11 (29.73%) 12 (32.43%) 14 (37.84%)   
CT 46 13 (28.26%) 15 (32.61%) 18 (39.13%)   
TT 17 8 47.06%) 7 (41.18%) 2 (11.76%) 69.084 <0.001
C 101 30 (29.70%) 34 (33.66%) 37 (36.63%)   
T 99 35 (35.35%) 33 (33.33%) 31 (31.31%) −2.081 0.037
Meta-analyses b CC 275 108 (39.27%) 68 (24.73%) 99 (36.00%)   
CT 196 79 (40.31%) 55 (28.06%) 62 3(31.63%)   
TT 94 48 (51.06%) 31 (32.98%) 15 (15.96%) 395.200 <0.001
C 730 273 (37.40%) 199 (27.26%) 258 (35.34%)   
T 400 180 (45.00) 120 (30.00%) 100 (25.00%) −28.366 <0.001
  1. TRAIL tumor necrosis factor related apoptosis-inducing ligand, IDD intervertebral disc degeneration
  2. a χ2 value was calculated by Kruskal-Wallis H, and Z value by Mann-Whitney Test
  3. b Double-arcsine-transformed prevalence method was used to perform meta-analyses of prevalences