Table 3 Meta-analysis of disc degeneration grades among IDD patients with different TRAIL 1595C/T genotypes and alleles
Author | Genotypes or alleles | n | Grade II | Grade III | Grade IV | χ2 or Z value a | P value |
|---|---|---|---|---|---|---|---|
Zhang [10] | CC | 192 | 94 (48.96%) | 42 (21.88%) | 56 (29.17%) | ||
CT | 79 | 48 (60.76%) | 22 (27.85%) | 9 (11.39%) | |||
TT | 41 | 20 (48.78%) | 15 (36.59%) | 6 (14.63%) | 175.400 | <0.001 | |
C | 463 | 236 (50.97%) | 106 (22.89%) | 121 (26.13%) | |||
T | 161 | 88 (54.66%) | 52 (32.30%) | 21 (13.04%) | −19.612 | <0.001 | |
Du [8] | CC | 46 | 14 (30.43%) | 12 (26.09%) | 20 (43.48%) | ||
CT | 71 | 22 (30.99%) | 18 (25.35%) | 31 (43.66%) | |||
TT | 36 | 20 (55.56%) | 9 (25.00%) | 7 (19.44%) | 66.501 | <0.001 | |
C | 163 | 50 (30.67%) | 42 (25.77%) | 71 (43.56%) | |||
T | 143 | 62 (43.36%) | 36 (25.17%) | 45 (31.47%) | −5.346 | <0.001 | |
Xu [9] | CC | 37 | 11 (29.73%) | 12 (32.43%) | 14 (37.84%) | ||
CT | 46 | 13 (28.26%) | 15 (32.61%) | 18 (39.13%) | |||
TT | 17 | 8 47.06%) | 7 (41.18%) | 2 (11.76%) | 69.084 | <0.001 | |
C | 101 | 30 (29.70%) | 34 (33.66%) | 37 (36.63%) | |||
T | 99 | 35 (35.35%) | 33 (33.33%) | 31 (31.31%) | −2.081 | 0.037 | |
Meta-analyses b | CC | 275 | 108 (39.27%) | 68 (24.73%) | 99 (36.00%) | ||
CT | 196 | 79 (40.31%) | 55 (28.06%) | 62 3(31.63%) | |||
TT | 94 | 48 (51.06%) | 31 (32.98%) | 15 (15.96%) | 395.200 | <0.001 | |
C | 730 | 273 (37.40%) | 199 (27.26%) | 258 (35.34%) | |||
T | 400 | 180 (45.00) | 120 (30.00%) | 100 (25.00%) | −28.366 | <0.001 |