Table 5 Spearman rho correlation coefficients and associated p-values for correlations between total wear volume, wear rate, indirect markers of wear (whole blood and synovial fluid metal ion concentrations) and histopathological grading (Natu and ALVAL)
Natu grading | ALVAL grading | ||||||
|---|---|---|---|---|---|---|---|
Lymphocytic cuffing | Macrophage sheet thickness | Grade of necrosis | Inflammatory infiltrate score | Synovial lining score | Tissue organization score | Total ALVAL score | |
Total wear volume | rho = 0.11 p = 0.32 | rho = 0.25* p = 0.020 | rho = 0.35* p < 0.01 | rho = 0.13 p = 0.23 | rho = 0.37* p < 0.01 | rho = 0.25* p = 0.023 | rho = 0.31* p < 0.01 |
Wear rate | rho = 0.17 p = 0.12 | rho = 0.20 p = 0.069 | rho = 0.42* p < 0.0001 | rho = 0.16 p = 0.15 | rho = 0.48* p < 0.0001 | rho = 0.35* p < 0.01 | rho = 0.40* p < 0.001 |
WB Cr | rho = 0.089 p = 0.51 | rho = 0.30* p = 0.024 | rho = 0.45* p < 0.001 | rho = 0.19 p = 0.26 | rho = 0.54* p < 0.001 | rho = 0.33* p = 0.015 | rho = 0.48* p < 0.001 |
WB Co | rho = 0.18 p = 0.18 | rho = 0.29* p = 0.029 | rho = 0.51* p < 0.001 | rho = 0.26 p = 0.055 | rho = 0.60* p < 0.001 | rho = 0.40* p < 0.01 | rho = 0.55* p < 0.001 |
SF Cr | rho = 0.30 p = 0.12 | rho = 0.16 p = 0.40 | rho = 0.48* p < 0.01 | rho = 0.25 p = 0.19 | rho = 0.56* p < 0.01 | rho = 0.34 p = 0.070 | rho = 0.53* p < 0.01 |
SF Co | rho = 0.49* p < 0.01 | rho = 0.17 p = 0.37 | rho = 0.54* p < 0.01 | rho = 0.44* p = 0.017 | rho = 0.47* p = 0.011 | rho = 0.38* p = 0.045 | rho = 0.57* p < 0.01 |