|
Time point
|
Control group
|
OVX group
|
t value
|
P value
|
|---|
|
Emax
|
|
Baseline
|
1.51 ± 0.19
|
1.51 ± 0.06
|
0.000
|
1.000
|
|
Week 3
|
1.53 ± 0.34
|
1.35 ± 0.14
|
1.053
|
0.323
|
|
Week 6
|
1.69 ± 0.19
|
1.30 ± 0.09
|
4.182
|
0.003#
|
|
Week 9
|
1.58 ± 0.09
|
1.26 ± 0.16
|
3.971
|
0.004#
|
|
Week 12
|
1.39 ± 0.16
|
1.35 ± 0.16
|
0.313
|
0.762
|
|
Ktrans (min−1)
|
|
Baseline
|
0.29 ± 0.06
|
0.34 ± 0.03
|
−1.653
|
0.137
|
|
Week 3
|
0.28 ± 0.08
|
0.18 ± 0.03*
|
2.646
|
0.029#
|
|
Week 6
|
0.29 ± 0.07
|
0.20 ± 0.02*
|
2.691
|
0.027#
|
|
Week 9
|
0.26 ± 0.08
|
0.18 ± 0.01*
|
2.462
|
0.039#
|
|
Week 12
|
0.25 ± 0.06
|
0.16 ± 0.02*
|
2.724
|
0.041#
|
|
Ve (mL/100 mL)
|
|
Baseline
|
0.36 ± 0.08
|
0.38 ± 0.09
|
−0.376
|
0.716
|
|
Week 3
|
0.41 ± 0.18
|
0.25 ± 0.07
|
1.825
|
0.105
|
|
Week 6
|
0.37 ± 0.08
|
0.29 ± 0.05
|
1.825
|
0.105
|
|
Week 9
|
0.33 ± 0.08
|
0.22 ± 0.05*
|
2.600
|
0.032#
|
|
Week 12
|
0.27 ± 0.05
|
0.25 ± 0.06
|
0.556
|
0.594
|
|
Kep (min−1)
|
|
Baseline
|
0.79 ± 0.08
|
0.94 ± 0.18
|
−1.667
|
0.134
|
|
Week 3
|
0.70 ± 0.29
|
0.84 ± 0.22
|
−0.868
|
0.410
|
|
Week 6
|
0.77 ± 0.15
|
0.71 ± 0.18
|
0.560
|
0.591
|
|
Week 9
|
0.80 ± 0.23
|
0.82 ± 0.24
|
−0.194
|
0.851
|
|
Week 12
|
0.86 ± 0.16
|
0.65 ± 0.15
|
2.224
|
0.057
|
- Data are expressed as the means ± standard deviations. OVX group represents the rats underwent bilateral ovariectomy. Control group represents the rats underwent sham operation
-
*
P < 0 .05, versus baseline in the same group
-
#
P < 0.05, control group versus OVX group at the same time point
