Comparison of semi-quantitative and quantitative dynamic contrast-enhanced MRI evaluations of vertebral marrow perfusion in a rat osteoporosis model

Table 1 DCE-MRI parameters of L5 vertebral bodies at five time points

Time point	Control group	OVX group	t value	P value
E_max
Baseline	1.51 ± 0.19	1.51 ± 0.06	0.000	1.000
Week 3	1.53 ± 0.34	1.35 ± 0.14	1.053	0.323
Week 6	1.69 ± 0.19	1.30 ± 0.09	4.182	0.003^#
Week 9	1.58 ± 0.09	1.26 ± 0.16	3.971	0.004^#
Week 12	1.39 ± 0.16	1.35 ± 0.16	0.313	0.762
K^trans (min⁻¹)
Baseline	0.29 ± 0.06	0.34 ± 0.03	−1.653	0.137
Week 3	0.28 ± 0.08	0.18 ± 0.03^*	2.646	0.029^#
Week 6	0.29 ± 0.07	0.20 ± 0.02^*	2.691	0.027^#
Week 9	0.26 ± 0.08	0.18 ± 0.01^*	2.462	0.039^#
Week 12	0.25 ± 0.06	0.16 ± 0.02^*	2.724	0.041^#
V_e (mL/100 mL)
Baseline	0.36 ± 0.08	0.38 ± 0.09	−0.376	0.716
Week 3	0.41 ± 0.18	0.25 ± 0.07	1.825	0.105
Week 6	0.37 ± 0.08	0.29 ± 0.05	1.825	0.105
Week 9	0.33 ± 0.08	0.22 ± 0.05^*	2.600	0.032^#
Week 12	0.27 ± 0.05	0.25 ± 0.06	0.556	0.594
K_ep (min⁻¹)
Baseline	0.79 ± 0.08	0.94 ± 0.18	−1.667	0.134
Week 3	0.70 ± 0.29	0.84 ± 0.22	−0.868	0.410
Week 6	0.77 ± 0.15	0.71 ± 0.18	0.560	0.591
Week 9	0.80 ± 0.23	0.82 ± 0.24	−0.194	0.851
Week 12	0.86 ± 0.16	0.65 ± 0.15	2.224	0.057

Data are expressed as the means ± standard deviations. OVX group represents the rats underwent bilateral ovariectomy. Control group represents the rats underwent sham operation
^* P < 0 .05, versus baseline in the same group
^# P < 0.05, control group versus OVX group at the same time point