Fig. 1

Effects of DMM, OVX and PAI-1 deficiency on the BMD of the tibial subchondral bone in mice. a qCT images of the subchondral bone in WT and PAI-1 KO mice 8 weeks after DMM or sham surgery with or without OVX. b The trabecular BMD of the subchondral bone was assessed by qCT in WT and PAI-1 KO mice 8 weeks after DMM or sham surgery with or without OVX. Regions of interest were defined as 240-μm (10-slice) segments from 72 μm proximal to the end of the proximal growth plate towards the joint. Data represent the mean ± SEM of 10–11 mice. **p < 0.01 and *p < 0.05. c Hematoxylin and Eosin-stained sections from the subchondral bone in WT and PAI-1 KO mice 8 weeks after DMM or sham surgery with or without OVX. Scale bars = 200 μm