Latent class analysis derived subgroups of low back pain patients – do they have prognostic capacity?

Molgaard Nielsen, Anne; Hestbaek, Lise; Vach, Werner; Kent, Peter; Kongsted, Alice

doi:10.1186/s12891-017-1708-9

BMC Musculoskeletal Disorders

Table 6 Prognostic capacity in addition to that of the participants’ recovery beliefs

From: Latent class analysis derived subgroups of low back pain patients – do they have prognostic capacity?

			Follow-up time points
Outcome measure	Description of prognostic variable	Prognostic variable	2 weeks	3 months	12 months
Outcome measure	Description of prognostic variable	Prognostic variable	Diff. of. adj. R²	Diff. of. adj. R²	Diff. of. adj. R²
Pain intensity (Numeric Rating Scale, 0–10)	LCA-derived subgroupings	Single-stage subgroups	0.041**	0.013*	0.033**
	LCA-derived subgroupings	Two-stage subgroups	0.039**	0.015*	0.021*
	Existing subgrouping tools	STarT Back Tool	0.023**	0.004	0.008*
	Existing subgrouping tools	Quebec Task Force classification	0.007	0.012*	0.005
	Baseline characteristics	Baseline back pain intensity (0–10 Numeric Rating Scale)	0.024**	0.002*	−0.003*
		Baseline leg pain intensity (0–10 Numeric Rating Scale)	0.049**	0.004*	0.027**
		Baseline disability (RMDQ-23) (0–100 = highest disability)	0.026**	0.001	0.007*
	Results of first stage of two-stage LCA	All domain-specific patient categorisations	0.052**	0.047**	0.074**
Disability (23-item Roland Morris Disability Questionnaire, proportional score)	LCA-derived subgroupings	Single-stage subgroups	0.183**	0.084**	0.051**
	LCA-derived subgroupings	Two-stage subgroups	0.174**	0.084**	0.044**
	Existing subgrouping tools	STarT Back Tool	0.105**	0.059**	0.023**
	Existing subgrouping tools	Quebec Task Force classification	0.033**	0.037**	0.029*
	Baseline characteristics	Baseline back pain intensity (0–10 Numeric Rating Scale)	0.057**	0.013*	0.009*
		Baseline leg pain intensity (0–10 Numeric Rating Scale)	0.052**	0.036**	0.048**
		Baseline disability (RMDQ-23) (0–100 = highest disability)	0.199**	0.069**	0.049**
	Results of first stage of two-stage LCA	All domain-specific patient categorisations	0.232**	0.123**	0.101**

Diff. of. adj. R² = difference in adjusted R² obtained when the prognostic variable was added; LCA Latent Class Analysis
*P < .05
**P < .001

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ISSN: 1471-2474

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