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Table 3 Genes the expression levels of which responded to prednisolone treatment in a given direction only in patients with polymyalgia rheumatica (131 genes)

From: Gene expression profiling in patients with polymyalgia rheumatica before and after symptom-abolishing glucocorticoid treatment

Gene symbol Gene name Probe set(s) FCa p
COL1A1 collagen, type I, alpha 1 1556499_s_at +4.7 0.028
CTGF connective tissue growth factor 209101_at +2.9 0.012
MEST mesoderm specific transcript homolog (mouse) 202016_at +2.7 0.049
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 207173_x_at +2.6 0.012
S1PR3 sphingosine-1-phosphate receptor 3 228176_at +2.5 0.009
CD248 CD248 molecule, endosialin 219025_at +2.5 0.019
FBN1 fibrillin 1 202766_s_at 235318_at +2.4 +2.1 0.031 0.017
NINJ2 ninjurin 2 219594_at +2.3 0.002
MFAP5 microfibrillar associated protein 5 209758_s_at 213764_s_at 213765_at +2.7 +2.2 +2.1 0.038 0.010 0.018
SH3PXD2B SH3 and PX domains 2B 231823_s_at +2.2 0.011
C13orf33 chromosome 13 open reading frame 33 227058_at +2.2 0.044
FOSL2 FOS-like antigen 2 218880_at +2.2 0.026
BGN biglycan 201261_x_at +2.1 0.029
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 233223_at +2.1 0.004
COL5A2 collagen, type V, alpha 2 221730_at +2.0 0.049
NT5E 5′-nucleotidase, ecto (CD73) 203939_at +2.0 0.044
TUBB6 tubulin, beta 6 class V 209191_at +2.0 0.031
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 200665_s_at +2.0 0.043
FN1 fibronectin 1 210495_x_at 211719_x_at 212464_s_at 216442_x_at +1.9 +1.9 +1.9 +2.0 0.045 0.042 0.046 0.038
GFPT2 glutamine-fructose-6-phosphate transaminase 2 205100_at +1.9 0.034
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 223217_s_at +1.9 0.025
DCLK1 doublecortin-like kinase 1 205399_at +1.9 0.034
METRNL meteorin, glial cell differentiation regulator-like 225955_at +1.9 0.023
COL1A2 collagen, type I, alpha 2 229218_at +1.8 0.048
LAMB1 laminin, beta 1 201505_at +1.8 0.003
LSP1P1 lymphocyte-specific protein 1 pseudogene 214110_s_at +1.8 0.020
COL6A3 collagen, type VI, alpha 3 201438_at +1.8 0.003
GAS7 growth arrest-specific 7 202191_s_at 202192_s_at +1.8 +1.7 0.028 0.021
ARHGAP26 Rho GTPase activating protein 26 244548_at +1.8 0.003
OLFML2B olfactomedin-like 2B 213125_at +1.7 0.031
SPON2 spondin 2, extracellular matrix protein 218638_s_at +1.7 0.002
COL6A1 collagen, type VI, alpha 1 213428_s_at +1.7 0.006
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 206227_at +1.7 0.012
OLFML3 olfactomedin-like 3 218162_at +1.7 0.026
FAM69A family with sequence similarity 69, member A 213689_x_at +1.7 <0.001
CORO1C coronin, actin binding protein, 1C 222409_at +1.6 0.020
MAP1B microtubule-associated protein 1B 226084_at +1.6 0.039
COL6A2 collagen, type VI, alpha 2 209156_s_at +1.6 0.020
PRKCDBP protein kinase C, delta binding protein 213010_at +1.6 <0.001
CLIC4 chloride intracellular channel 4 201560_at +1.6 0.010
LRRN4CL LRRN4 C-terminal like 1556427_s_at +1.5 0.006
CD109 CD109 molecule 226545_at +1.5 0.034
DBN1 drebrin 1 202806_at +1.5 0.020
SFXN3 sideroflexin 3 220974_x_at +1.5 0.016
TNXA / TNXB tenascin XA (pseudogene) / tenascin XB 206093_x_at 213451_x_at 216333_x_at +1.5 +1.5 +1.5 0.030 0.034 0.041
PRSS23 protease, serine, 23 202458_at +1.5 0.022
TUBA1A tubulin, alpha 1a 209118_s_at +1.5 0.038
SAMHD1 SAM domain and HD domain 1 235529_x_at +1.5 0.024
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 219829_at +1.5 0.003
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 209934_s_at +1.5 <0.001
PXDC1 PX domain containing 1 212923_s_at +1.5 0.014
PAQR9 progestin and adipoQ receptor family member IX 1558322_a_at +1.4 0.027
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 202733_at +1.4 0.024
ANXA2 annexin A2 201590_x_at 210427_x_at 213503_x_at +1.4 +1.4 +1.4 0.025 0.027 0.032
ACVRL1 activin A receptor type II-like 1 226950_at +1.4 0.009
CHSY1 chondroitin sulfate synthase 1 203044_at +1.4 0.021
C10orf54 chromosome 10 open reading frame 54 225373_at +1.4 0.016
PLAGL1 pleiomorphic adenoma gene-like 1 207943_x_at +1.4 0.012
CTTNBP2NL CTTNBP2 N-terminal like 226000_at +1.4 0.019
SYNPO2 synaptopodin 2 225720_at +1.4 0.013
ANXA2P2 annexin A2 pseudogene 2 208816_x_at +1.4 0.042
TGFB1I1 transforming growth factor beta 1 induced transcript 1 209651_at +1.4 0.043
ACTB actin, beta 213867_x_at 224594_x_at 200801_x_at +1.4 +1.4 +1.4 0.048 0.040 0.033
TRIO triple functional domain (PTPRF interacting) 208178_x_at 209012_at +1.4 0.018
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 201389_at +1.4 0.038
RRBP1 ribosome binding protein 1 homolog 180 kDa (dog) 201204_s_at +1.4 0.010
LASP1 LIM and SH3 protein 1 200618_at +1.4 0.016
ADNP2 ADNP homeobox 2 203321_s_at +1.3 0.009
MTFP1 mitochondrial fission process 1 223172_s_at +1.3 0.017
TP53INP2 tumor protein p53 inducible nuclear protein 2 224836_at +1.3 0.017
PDGFRB platelet-derived growth factor receptor, beta polypeptide 202273_at +1.3 0.009
FBXO9 F-box protein 9 210638_s_at 212987_at +1.3 +1.3 0.002 <0.001
VAT1 vesicle amine transport protein 1 homolog (T. californica) 208626_s_at +1.3 0.043
LTBP1 latent transforming growth factor beta binding protein 1 202729_s_at +1.3 0.026
HIF1A hypoxia inducible factor 1, alpha subunit 200989_at +1.3 0.025
SH3KBP1 SH3-domain kinase binding protein 1 1554168_a_at 223082_at +1.3 +1.3 0.044 0.027
JARID2 jumonji, AT rich interactive domain 2 203297_s_at +1.3 0.007
ACTG1 actin, gamma 1 201550_x_at 211970_x_at 211983_x_at 211995_x_at 212363_x_at 212988_x_at 213214_x_at +1.3 +1.3 +1.3 +1.3 +1.3 +1.3 +1.3 0.015 0.009 0.031 0.013 0.020 0.017 0.021
MAP2K3 mitogen-activated protein kinase kinase 3 215499_at +1.3 0.021
MEMO1 mediator of cell motility 1 219065_s_at +1.3 0.012
EZR ezrin 208623_s_at +1.3 0.002
BPGM 2,3-bisphosphoglycerate mutase 203502_at +1.2 0.036
TUBB tubulin, beta class I 212320_at +1.2 0.039
DDAH1 dimethylarginine dimethylaminohydrolase 1 209094_at +1.2 0.033
BDNF brain-derived neurotrophic factor 244503_at −3.1 0.001
SLC25A34 solute carrier family 25, member 34 1559977_a_at 232245_at −1.9 −1.9 0.006 0.009
SVIP small VCP/p97-interacting protein 230285_at −1.7 0.004
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 239917_at −1.6 <0.001
PIAS2 protein inhibitor of activated STAT, 2 244633_at −1.6 0.011
LOC100507303 uncharacterized LOC100507303 228049_x_at −1.6 0.004
RPL37 ribosomal protein L37 224763_at −1.5 <0.001
TMTC1 transmembrane and tetratricopeptide repeat containing 1 226322_at 226931_at −1.4 −1.6 0.005 <0.001
MLYCD malonyl-CoA decarboxylase 218869_at −1.5 0.004
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 207349_s_at −1.5 0.016
TUBD1 tubulin, delta 1 231853_at −1.4 0.003
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 202331_at −1.4 0.004
TRIM39 tripartite motif containing 39 222732_at −1.4 0.002
ZNF331 zinc finger protein 331 219228_at −1.4 0.003
NRBF2 nuclear receptor binding factor 2 223650_s_at −1.4 0.021
GTF2H5 general transcription factor IIH, polypeptide 5 244294_at −1.4 0.007
FMO2 flavin containing monooxygenase 2 (non-functional) 228268_at −1.4 0.002
TMEM18 transmembrane protein 18 225489_at −1.4 0.028
HSDL2 Hydroxysteroid dehydrogenase like 2 215436_at −1.4 0.006
N4BP2L1 NEDD4 binding protein 2-like 1 213375_s_at −1.4 0.033
PEBP4 phosphatidylethanolamine-binding protein 4 227848_at −1.4 0.009
RANBP9 RAN binding protein 9 216125_s_at −1.4 0.002
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 203217_s_at −1.3 0.003
ACADSB acyl-CoA dehydrogenase, short/branched chain 226030_at −1.3 0.006
RNF114 ring finger protein 114 200867_at 200868_s_at 211678_s_at −1.3 −1.3 −1.2 0.020 0.030 0.041
MRPS2 mitochondrial ribosomal protein S2 218001_at −1.3 0.006
TMEM50B transmembrane protein 50B 219600_s_at −1.3 0.027
EIF3G eukaryotic translation initiation factor 3, subunit G 208887_at −1.3 0.005
PSIP1 PC4 and SFRS1 interacting protein 1 209337_at −1.3 0.007
PTP4A1 protein tyrosine phosphatase type IVA, member 1 200732_s_at −1.3 <0.001
EIF4B eukaryotic translation initiation factor 4B 211937_at −1.3 0.015
FAM184B family with sequence similarity 184, member B 235288_at −1.3 0.042
CNNM3 cyclin M3 229031_at −1.3 0.011
RERE arginine-glutamic acid dipeptide (RE) repeats 200940_s_at −1.3 0.008
ZNF195 zinc finger protein 195 204234_s_at −1.3 0.002
SNRPA small nuclear ribonucleoprotein polypeptide A 201770_at −1.3 0.025
TM4SF18 transmembrane 4 L six family member 18 230061_at −1.3 0.033
RPL36AL ribosomal protein L36a-like 207585_s_at −1.2 0.008
RBBP6 retinoblastoma binding protein 6 212783_at −1.2 0.025
TSFM Ts translation elongation factor, mitochondrial 214331_at −1.2 0.019
POLR1B polymerase (RNA) I polypeptide B, 128 kDa 223403_s_at −1.2 0.018
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 221691_x_at −1.2 0.022
OXA1L oxidase (cytochrome c) assembly 1-like 208717_at −1.2 0.027
RSBN1 round spermatid basic protein 1 213694_at −1.2 0.016
AKR7A2 aldo-keto reductase family 7, member A2 202139_at −1.2 0.002
RORA RAR-related orphan receptor A 226682_at −1.2 0.044
DFFA DNA fragmentation factor, 45 kDa, alpha polypeptide 226116_at −1.2 0.016
  1. FC, fold change. Entries in bold indicate that genes also responded significantly (but in the opposite direction) in control subjects. Responses in controls for both these genes, TNXA/TNXB and RORA, were of the same magnitude as in patients but in the opposite direction. afold changes for genes with more than one probe set were calculated as the average of the individual values, which did not differ markedly