Table 3 Genes the expression levels of which responded to prednisolone treatment in a given direction only in patients with polymyalgia rheumatica (131 genes)
Gene symbol | Gene name | Probe set(s) | FCa | p |
|---|---|---|---|---|
COL1A1 | collagen, type I, alpha 1 | 1556499_s_at | +4.7 | 0.028 |
CTGF | connective tissue growth factor | 209101_at | +2.9 | 0.012 |
MEST | mesoderm specific transcript homolog (mouse) | 202016_at | +2.7 | 0.049 |
CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 207173_x_at | +2.6 | 0.012 |
S1PR3 | sphingosine-1-phosphate receptor 3 | 228176_at | +2.5 | 0.009 |
CD248 | CD248 molecule, endosialin | 219025_at | +2.5 | 0.019 |
FBN1 | fibrillin 1 | 202766_s_at 235318_at | +2.4 +2.1 | 0.031 0.017 |
NINJ2 | ninjurin 2 | 219594_at | +2.3 | 0.002 |
MFAP5 | microfibrillar associated protein 5 | 209758_s_at 213764_s_at 213765_at | +2.7 +2.2 +2.1 | 0.038 0.010 0.018 |
SH3PXD2B | SH3 and PX domains 2B | 231823_s_at | +2.2 | 0.011 |
C13orf33 | chromosome 13 open reading frame 33 | 227058_at | +2.2 | 0.044 |
FOSL2 | FOS-like antigen 2 | 218880_at | +2.2 | 0.026 |
BGN | biglycan | 201261_x_at | +2.1 | 0.029 |
NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 233223_at | +2.1 | 0.004 |
COL5A2 | collagen, type V, alpha 2 | 221730_at | +2.0 | 0.049 |
NT5E | 5′-nucleotidase, ecto (CD73) | 203939_at | +2.0 | 0.044 |
TUBB6 | tubulin, beta 6 class V | 209191_at | +2.0 | 0.031 |
SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 200665_s_at | +2.0 | 0.043 |
FN1 | fibronectin 1 | 210495_x_at 211719_x_at 212464_s_at 216442_x_at | +1.9 +1.9 +1.9 +2.0 | 0.045 0.042 0.046 0.038 |
GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 205100_at | +1.9 | 0.034 |
NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 223217_s_at | +1.9 | 0.025 |
DCLK1 | doublecortin-like kinase 1 | 205399_at | +1.9 | 0.034 |
METRNL | meteorin, glial cell differentiation regulator-like | 225955_at | +1.9 | 0.023 |
COL1A2 | collagen, type I, alpha 2 | 229218_at | +1.8 | 0.048 |
LAMB1 | laminin, beta 1 | 201505_at | +1.8 | 0.003 |
LSP1P1 | lymphocyte-specific protein 1 pseudogene | 214110_s_at | +1.8 | 0.020 |
COL6A3 | collagen, type VI, alpha 3 | 201438_at | +1.8 | 0.003 |
GAS7 | growth arrest-specific 7 | 202191_s_at 202192_s_at | +1.8 +1.7 | 0.028 0.021 |
ARHGAP26 | Rho GTPase activating protein 26 | 244548_at | +1.8 | 0.003 |
OLFML2B | olfactomedin-like 2B | 213125_at | +1.7 | 0.031 |
SPON2 | spondin 2, extracellular matrix protein | 218638_s_at | +1.7 | 0.002 |
COL6A1 | collagen, type VI, alpha 1 | 213428_s_at | +1.7 | 0.006 |
CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 206227_at | +1.7 | 0.012 |
OLFML3 | olfactomedin-like 3 | 218162_at | +1.7 | 0.026 |
FAM69A | family with sequence similarity 69, member A | 213689_x_at | +1.7 | <0.001 |
CORO1C | coronin, actin binding protein, 1C | 222409_at | +1.6 | 0.020 |
MAP1B | microtubule-associated protein 1B | 226084_at | +1.6 | 0.039 |
COL6A2 | collagen, type VI, alpha 2 | 209156_s_at | +1.6 | 0.020 |
PRKCDBP | protein kinase C, delta binding protein | 213010_at | +1.6 | <0.001 |
CLIC4 | chloride intracellular channel 4 | 201560_at | +1.6 | 0.010 |
LRRN4CL | LRRN4 C-terminal like | 1556427_s_at | +1.5 | 0.006 |
CD109 | CD109 molecule | 226545_at | +1.5 | 0.034 |
DBN1 | drebrin 1 | 202806_at | +1.5 | 0.020 |
SFXN3 | sideroflexin 3 | 220974_x_at | +1.5 | 0.016 |
TNXA / TNXB | tenascin XA (pseudogene) / tenascin XB | 206093_x_at 213451_x_at 216333_x_at | +1.5 +1.5 +1.5 | 0.030 0.034 0.041 |
PRSS23 | protease, serine, 23 | 202458_at | +1.5 | 0.022 |
TUBA1A | tubulin, alpha 1a | 209118_s_at | +1.5 | 0.038 |
SAMHD1 | SAM domain and HD domain 1 | 235529_x_at | +1.5 | 0.024 |
ITGB1BP2 | integrin beta 1 binding protein (melusin) 2 | 219829_at | +1.5 | 0.003 |
ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 209934_s_at | +1.5 | <0.001 |
PXDC1 | PX domain containing 1 | 212923_s_at | +1.5 | 0.014 |
PAQR9 | progestin and adipoQ receptor family member IX | 1558322_a_at | +1.4 | 0.027 |
P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 202733_at | +1.4 | 0.024 |
ANXA2 | annexin A2 | 201590_x_at 210427_x_at 213503_x_at | +1.4 +1.4 +1.4 | 0.025 0.027 0.032 |
ACVRL1 | activin A receptor type II-like 1 | 226950_at | +1.4 | 0.009 |
CHSY1 | chondroitin sulfate synthase 1 | 203044_at | +1.4 | 0.021 |
C10orf54 | chromosome 10 open reading frame 54 | 225373_at | +1.4 | 0.016 |
PLAGL1 | pleiomorphic adenoma gene-like 1 | 207943_x_at | +1.4 | 0.012 |
CTTNBP2NL | CTTNBP2 N-terminal like | 226000_at | +1.4 | 0.019 |
SYNPO2 | synaptopodin 2 | 225720_at | +1.4 | 0.013 |
ANXA2P2 | annexin A2 pseudogene 2 | 208816_x_at | +1.4 | 0.042 |
TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 209651_at | +1.4 | 0.043 |
ACTB | actin, beta | 213867_x_at 224594_x_at 200801_x_at | +1.4 +1.4 +1.4 | 0.048 0.040 0.033 |
TRIO | triple functional domain (PTPRF interacting) | 208178_x_at 209012_at | +1.4 | 0.018 |
ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 201389_at | +1.4 | 0.038 |
RRBP1 | ribosome binding protein 1 homolog 180 kDa (dog) | 201204_s_at | +1.4 | 0.010 |
LASP1 | LIM and SH3 protein 1 | 200618_at | +1.4 | 0.016 |
ADNP2 | ADNP homeobox 2 | 203321_s_at | +1.3 | 0.009 |
MTFP1 | mitochondrial fission process 1 | 223172_s_at | +1.3 | 0.017 |
TP53INP2 | tumor protein p53 inducible nuclear protein 2 | 224836_at | +1.3 | 0.017 |
PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 202273_at | +1.3 | 0.009 |
FBXO9 | F-box protein 9 | 210638_s_at 212987_at | +1.3 +1.3 | 0.002 <0.001 |
VAT1 | vesicle amine transport protein 1 homolog (T. californica) | 208626_s_at | +1.3 | 0.043 |
LTBP1 | latent transforming growth factor beta binding protein 1 | 202729_s_at | +1.3 | 0.026 |
HIF1A | hypoxia inducible factor 1, alpha subunit | 200989_at | +1.3 | 0.025 |
SH3KBP1 | SH3-domain kinase binding protein 1 | 1554168_a_at 223082_at | +1.3 +1.3 | 0.044 0.027 |
JARID2 | jumonji, AT rich interactive domain 2 | 203297_s_at | +1.3 | 0.007 |
ACTG1 | actin, gamma 1 | 201550_x_at 211970_x_at 211983_x_at 211995_x_at 212363_x_at 212988_x_at 213214_x_at | +1.3 +1.3 +1.3 +1.3 +1.3 +1.3 +1.3 | 0.015 0.009 0.031 0.013 0.020 0.017 0.021 |
MAP2K3 | mitogen-activated protein kinase kinase 3 | 215499_at | +1.3 | 0.021 |
MEMO1 | mediator of cell motility 1 | 219065_s_at | +1.3 | 0.012 |
EZR | ezrin | 208623_s_at | +1.3 | 0.002 |
BPGM | 2,3-bisphosphoglycerate mutase | 203502_at | +1.2 | 0.036 |
TUBB | tubulin, beta class I | 212320_at | +1.2 | 0.039 |
DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 209094_at | +1.2 | 0.033 |
BDNF | brain-derived neurotrophic factor | 244503_at | −3.1 | 0.001 |
SLC25A34 | solute carrier family 25, member 34 | 1559977_a_at 232245_at | −1.9 −1.9 | 0.006 0.009 |
SVIP | small VCP/p97-interacting protein | 230285_at | −1.7 | 0.004 |
VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 239917_at | −1.6 | <0.001 |
PIAS2 | protein inhibitor of activated STAT, 2 | 244633_at | −1.6 | 0.011 |
LOC100507303 | uncharacterized LOC100507303 | 228049_x_at | −1.6 | 0.004 |
RPL37 | ribosomal protein L37 | 224763_at | −1.5 | <0.001 |
TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | 226322_at 226931_at | −1.4 −1.6 | 0.005 <0.001 |
MLYCD | malonyl-CoA decarboxylase | 218869_at | −1.5 | 0.004 |
UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | 207349_s_at | −1.5 | 0.016 |
TUBD1 | tubulin, delta 1 | 231853_at | −1.4 | 0.003 |
BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 202331_at | −1.4 | 0.004 |
TRIM39 | tripartite motif containing 39 | 222732_at | −1.4 | 0.002 |
ZNF331 | zinc finger protein 331 | 219228_at | −1.4 | 0.003 |
NRBF2 | nuclear receptor binding factor 2 | 223650_s_at | −1.4 | 0.021 |
GTF2H5 | general transcription factor IIH, polypeptide 5 | 244294_at | −1.4 | 0.007 |
FMO2 | flavin containing monooxygenase 2 (non-functional) | 228268_at | −1.4 | 0.002 |
TMEM18 | transmembrane protein 18 | 225489_at | −1.4 | 0.028 |
HSDL2 | Hydroxysteroid dehydrogenase like 2 | 215436_at | −1.4 | 0.006 |
N4BP2L1 | NEDD4 binding protein 2-like 1 | 213375_s_at | −1.4 | 0.033 |
PEBP4 | phosphatidylethanolamine-binding protein 4 | 227848_at | −1.4 | 0.009 |
RANBP9 | RAN binding protein 9 | 216125_s_at | −1.4 | 0.002 |
ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 203217_s_at | −1.3 | 0.003 |
ACADSB | acyl-CoA dehydrogenase, short/branched chain | 226030_at | −1.3 | 0.006 |
RNF114 | ring finger protein 114 | 200867_at 200868_s_at 211678_s_at | −1.3 −1.3 −1.2 | 0.020 0.030 0.041 |
MRPS2 | mitochondrial ribosomal protein S2 | 218001_at | −1.3 | 0.006 |
TMEM50B | transmembrane protein 50B | 219600_s_at | −1.3 | 0.027 |
EIF3G | eukaryotic translation initiation factor 3, subunit G | 208887_at | −1.3 | 0.005 |
PSIP1 | PC4 and SFRS1 interacting protein 1 | 209337_at | −1.3 | 0.007 |
PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 200732_s_at | −1.3 | <0.001 |
EIF4B | eukaryotic translation initiation factor 4B | 211937_at | −1.3 | 0.015 |
FAM184B | family with sequence similarity 184, member B | 235288_at | −1.3 | 0.042 |
CNNM3 | cyclin M3 | 229031_at | −1.3 | 0.011 |
RERE | arginine-glutamic acid dipeptide (RE) repeats | 200940_s_at | −1.3 | 0.008 |
ZNF195 | zinc finger protein 195 | 204234_s_at | −1.3 | 0.002 |
SNRPA | small nuclear ribonucleoprotein polypeptide A | 201770_at | −1.3 | 0.025 |
TM4SF18 | transmembrane 4 L six family member 18 | 230061_at | −1.3 | 0.033 |
RPL36AL | ribosomal protein L36a-like | 207585_s_at | −1.2 | 0.008 |
RBBP6 | retinoblastoma binding protein 6 | 212783_at | −1.2 | 0.025 |
TSFM | Ts translation elongation factor, mitochondrial | 214331_at | −1.2 | 0.019 |
POLR1B | polymerase (RNA) I polypeptide B, 128 kDa | 223403_s_at | −1.2 | 0.018 |
NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 221691_x_at | −1.2 | 0.022 |
OXA1L | oxidase (cytochrome c) assembly 1-like | 208717_at | −1.2 | 0.027 |
RSBN1 | round spermatid basic protein 1 | 213694_at | −1.2 | 0.016 |
AKR7A2 | aldo-keto reductase family 7, member A2 | 202139_at | −1.2 | 0.002 |
RORA | RAR-related orphan receptor A | 226682_at | −1.2 | 0.044 |
DFFA | DNA fragmentation factor, 45 kDa, alpha polypeptide | 226116_at | −1.2 | 0.016 |