From: The effect of zoledronic acid on type and volume of Modic changes among patients with low back pain
Volume of the primary Modic changea | Mean (SD) | Mean (SD) change | Age-adjusted analyses | Adjusted analyses | |||||
---|---|---|---|---|---|---|---|---|---|
ZA n = 19 | Placebo n = 20 | ZA | Placebo | Pb | Difference (95% CI) | Pc | Difference (95% CI) | Pd | |
Levela, n (%) | |||||||||
L2/3 | 4 (21.1) | 0 (0.0) | |||||||
L3/4 | 2 (10.5) | 5 (25.0) | |||||||
L4/5 | 6 (31.6) | 5 (25.0) | |||||||
L5/S1 | 7 (36.8) | 10 (50.0) | |||||||
Volume of M1a (cm3) | |||||||||
Baseline | 7.37 (4.58) | 5.04 (3.55) | |||||||
Follow-up | 6.54 (5.38) | 5.95 (4.46) | -0.83 (4.44) | 0.91 (4.02) | 0.21 | −1.79 (−4.58, 1.00) | 0.20 | −1.92 (−5.03, 1.19) | 0.22 |
Volume of M2a (cm3) | |||||||||
Baseline | 4.53 (4.00) | 5.87 (4.84) | |||||||
Follow-up | 6.94 (4.57) | 7.84 (6.78) | 2.40 (2.95) | 1.97 (4.20) | 0.71 | 0.34 (−2.07, 2.74) | 0.78 | 0.232 (−2.44, 2.90) | 0.86 |
Total volumea (cm3) | |||||||||
Baseline | 11.90 (5.27) | 10.91 (5.96) | |||||||
Follow-up | 13.48 (5.55) | 13.79 (6.64) | 1.58 (2.24) | 2.88 (3.92) | 0.21 | −1.45 (−3.55, 0.64) | 0.17 | −1.69 (−4.14, 0.76) | 0.17 |