Fig. 3From: Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosisSimulated % Emax for sCTX inhibition over 24Â h after ONO-5334 administration. Each symbol depicts sCTX inhibition obtained from the Emax equation using the plasma ONO-5334 concentrations shown in Fig. 2. Emax is the predicted maximum drug effect as 53.1% sCTX inhibitionBack to article page