Fig. 2

Early intervention delays and suppresses peripheral disease progression. Peripheral arthritis progression of mice receiving vehicle (open circle, N = 12) and ETN + PRD (filled circle, N = 15) in both treatment arms. The line up to the week 8 point includes mice from both the short-term and long-term treatment groups, as these animals are directly comparable up to this point. The line from week 9 to 12 includes only long-term treatment group mice. Cumulative arthritis score (inflammation of all 4 limbs of all animals are shown (mean ± SD). Animal numbers per group are listed in Table 1