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Fig 2 | BMC Musculoskeletal Disorders

Fig 2

From: Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

Fig 2

Mean Changes from Baseline in Weight-bearing Pain. Significant reduction in WBP was observed at 1 week after the last injection (−18 mm in HMWHA, P < 0.001 and −20 mm in XLHA, P < 0.001); and it was further evident at week 6 week and week 12. The changes observed at 12 weeks after the last injection were still significant in both groups (−29 mm in HMWHA, P < 0.001 and −33 mm in XLHA, P < 0.001). Reductions in WBP at V5, V6 and V7 from baseline were all significant (P < 0.001, paired t-test) in both groups. V, Visit; W, Week; Vertical arrows represent injections of investigational products; Error bars indicate 95% confidence interval of mean change

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