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Table 5 Mean serum creatinine (Cr) level, glomerular filtration rate (GFR), and bone turnover biomarkers in the ZA (zoledronic acid) and control groups as a function of time

From: Bone turnover and periprosthetic bone loss after cementless total hip arthroplasty can be restored by zoledronic acid: a prospective, randomized, open-label, controlled trial

  Baseline 6 weeks 12 weeks 6 months 1 year 2 years
Renal function
Cr (mg/dL)
  ZA group 0.79 (0.23) 0.76 (0.27) 0.81 (0.28) 0.85 (0.59) 0.78 (0.24) 0.76 (0.26)
  Control 0.83 (0.2) 0.81 (0.22) 0.79 (0.18) 0.79 (0.19) 0.76 (0.23) 0.79 (0.22)
GFR (mL/min)
  ZA group 59.39 (2.21) 60.08 (5) 61.84 (10.78) 77.56 (27.24) 83.8 (28.48) 93.9 (23.3)
  Control 59.63 (1.28) 59.78 (1.15) 63.16 (12.83) 73.82 (23.6) 79.45 (25.96) 87.3 (19.5)
 Ca (mg/dL)
  ZA group 9.53 (0.49) 9.34 (0.57) 9.52 (0.44) 9.46 (0.46) 9.43 (0.49) 9.37 (0.39)
  Control 9.57 (0.43) 9.2 (1.77) 9.54 (0.36) 9.47 (0.52) 9.13 (1.89) 9.24 (0.29)
Bone turnover biomarkers
Bone-specific alkaline phosphatase (μg/L)
  ZA group 78.6 (17.7) 77.3 (19.2)a 65.6 (11.7)b 67.5 (26.6) 68.7 (24.5) 66.5 (18.1)
  Control 76 (17.6) 89.4 (21.7) 83.3 (22.8) 74.5 (19.9) 73.2 (22.9) 74 (15.9)
Osteocalcin (ng/mL)
  ZA group 21.1 (8.7) 18.1 (7.9) 17.2 (10.2) 14.7 (5) 16.8 (7.2) 14.9 (7.2)
  Control 18.5 (10.3) 20.9 (13.2) 20.8 (11.5) 17.7 (6.4) 20.5 (10.4) 18.8 (8.6)
N-telopeptide of procollagen I (ng/mL)
  ZA group 53.9 (23.1) 57.1 (24.6)a 38.8 (16.9)b 30.5 (11.9)b 34.6 (19.5) 28.3 (11.3)a
  Control 43.2 (21.8) 80.7 (44) 69.7 (38) 57.5 (24.9) 50.4 (35.4) 44.3 (19.3)
  1. asignificant difference between groups (P < 0.05)
  2. bsignificant difference between groups (P < 0.001)