Table 5 Mean serum creatinine (Cr) level, glomerular filtration rate (GFR), and bone turnover biomarkers in the ZA (zoledronic acid) and control groups as a function of time
| Â | Baseline | 6Â weeks | 12Â weeks | 6Â months | 1Â year | 2Â years |
|---|---|---|---|---|---|---|
Renal function | ||||||
  Cr (mg/dL) | ||||||
  ZA group | 0.79 (0.23) | 0.76 (0.27) | 0.81 (0.28) | 0.85 (0.59) | 0.78 (0.24) | 0.76 (0.26) |
  Control | 0.83 (0.2) | 0.81 (0.22) | 0.79 (0.18) | 0.79 (0.19) | 0.76 (0.23) | 0.79 (0.22) |
  GFR (mL/min) | ||||||
  ZA group | 59.39 (2.21) | 60.08 (5) | 61.84 (10.78) | 77.56 (27.24) | 83.8 (28.48) | 93.9 (23.3) |
  Control | 59.63 (1.28) | 59.78 (1.15) | 63.16 (12.83) | 73.82 (23.6) | 79.45 (25.96) | 87.3 (19.5) |
 Ca (mg/dL) | ||||||
  ZA group | 9.53 (0.49) | 9.34 (0.57) | 9.52 (0.44) | 9.46 (0.46) | 9.43 (0.49) | 9.37 (0.39) |
  Control | 9.57 (0.43) | 9.2 (1.77) | 9.54 (0.36) | 9.47 (0.52) | 9.13 (1.89) | 9.24 (0.29) |
Bone turnover biomarkers | ||||||
  Bone-specific alkaline phosphatase (μg/L) | ||||||
  ZA group | 78.6 (17.7) | 77.3 (19.2)a | 65.6 (11.7)b | 67.5 (26.6) | 68.7 (24.5) | 66.5 (18.1) |
  Control | 76 (17.6) | 89.4 (21.7) | 83.3 (22.8) | 74.5 (19.9) | 73.2 (22.9) | 74 (15.9) |
  Osteocalcin (ng/mL) | ||||||
  ZA group | 21.1 (8.7) | 18.1 (7.9) | 17.2 (10.2) | 14.7 (5) | 16.8 (7.2) | 14.9 (7.2) |
  Control | 18.5 (10.3) | 20.9 (13.2) | 20.8 (11.5) | 17.7 (6.4) | 20.5 (10.4) | 18.8 (8.6) |
  N-telopeptide of procollagen I (ng/mL) | ||||||
  ZA group | 53.9 (23.1) | 57.1 (24.6)a | 38.8 (16.9)b | 30.5 (11.9)b | 34.6 (19.5) | 28.3 (11.3)a |
  Control | 43.2 (21.8) | 80.7 (44) | 69.7 (38) | 57.5 (24.9) | 50.4 (35.4) | 44.3 (19.3) |