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Table 2 Data of subjective symptoms and adverse effects or serious adverse events in the included studies

From: Is hydroxychloroquine effective in treating primary Sjogren’s syndrome: a systematic review and meta-analysis

Author Year Region Total No. and No. of events Hydroxychloroquine Placebo
Gottenberg J.E. et al. 2014 France Total patients 56 64
No. of dry mouth 50 53
No. of improved (%) 21 (42.0) 22 (41.5)
No. of dry eyes 50 53
No. of improved (%) 21 (42.0) 22 (41.5)
No. of pain 46 47
No. of improved (%) 25 (54.3) 17 (36.2)
No. of fatigue 48 50
No. of improved (%) 11 (22.9) 14 (28.0)
No. of adverse effects - -
No. of serious adverse events 2 3
Fox R.I. et al. 1996 USA Total patients 50 -
No. of dry mouth 40 -
No. of improved (%) 23 (57.5) -
No. of dry eyes 40 -
No. of improved (%) 25 (62.5) -
No. of pain 40 -
No. of improved (%) 17 (42.5) -
No. of fatigue 40 -
No. of improved (%) 15 (37.5) -
No. of adverse effects 8 -
No. of serious adverse events - -
Kruize A.A. et al. 1993 Netherlands Total patients 10 9
No. of dry mouth 6 6
No. of improved (%) 2 (33.3) 3 (50.0)
No. of dry eyes 7 6
No. of improved (%) 3 (42.9) 4 (66.7)
No. of pain 2 4
No. of improved (%) 1 (50.0) 1 (25.0)
No. of fatigue 6 6
No. of improved (%) 4 (66.7) 5 (83.3)
No. of adverse effects 1 0
No. of serious adverse events - -