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Table 1 Quality assessment of included studies

From: Is hydroxychloroquine effective in treating primary Sjogren’s syndrome: a systematic review and meta-analysis

Author

Year

Region

Study design

Downs and Black quality score

OCEBM levels of evidence

Reporting (11)

External validity (3)

Internal validity - bias (7)

Internal validity - confounding (6)

Power (5)

Total (32)

Yoon C.H. et al.

2016

Korea

RCT

9

3

6

6

5

29

Level 2

Gottenberg J.E. et al.

2014

France

RCT

10

3

7

6

5

31

Level 2

Fox R.I. et al.

1996

USA

Retrospective

10

0

3

3

5

21

Level 4

Kruize A.A. et al.

1993

Netherlands

Cross-over

10

2

7

5

3

27

Level 2

  1. Abbreviations: OCEBM Oxford Centre for Evidence-Based Medicine, RCT randomized controlled trial