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Table 1 Quality assessment of included studies

From: Is hydroxychloroquine effective in treating primary Sjogren’s syndrome: a systematic review and meta-analysis

Author Year Region Study design Downs and Black quality score OCEBM levels of evidence
Reporting (11) External validity (3) Internal validity - bias (7) Internal validity - confounding (6) Power (5) Total (32)
Yoon C.H. et al. 2016 Korea RCT 9 3 6 6 5 29 Level 2
Gottenberg J.E. et al. 2014 France RCT 10 3 7 6 5 31 Level 2
Fox R.I. et al. 1996 USA Retrospective 10 0 3 3 5 21 Level 4
Kruize A.A. et al. 1993 Netherlands Cross-over 10 2 7 5 3 27 Level 2
  1. Abbreviations: OCEBM Oxford Centre for Evidence-Based Medicine, RCT randomized controlled trial