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Table 4 Sensitivity analyses for incidence of nonvertebral fractures in crossover (a) and long-term (b) subjects

From: Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

  1. A multiple imputation approach was used with varying assumptions (0, 20, 50, and 100% [ie, double]) of increased fracture risk after study discontinuation for subjects who withdrew early from the Extension relative to subjects who remained in the study. Colored boxes correspond to data plotted in Fig. 3