Fig. 4

Gait phenotype separation: blind testing of LDA Model 3. To validate our proposed methodology, we used a blind dataset pertaining to 81 dogs and investigated the capability of Model 3 to predict genotype based on gait assessment. Each row corresponds to an individual dog and each column to a specific time point (age). Colours denote predicted phenotype based on the results of gait analysis. Green, red, and yellow correspond, respectively, to gait patterns that resemble that of healthy dogs (p > 95%), are strictly different to that of healthy dogs but similar to that of GRMD dogs (p > 95%), and are strictly different to the gait patterns of both healthy (p < 5%) and GRMD dogs (p < 5%). Grey colour indicates that measurements were not available. Cells of the penultimate column, entitled Predicted, are coloured to reflect the predominant phenotype (Healthy or GRMD) predicted by the model for each dog. Thus, green and red cells indicate that the gait of the corresponding dog resembles that of a healthy and a GRMD dog, respectively. n.c. denotes an inconclusive prediction result. Cells in the rightmost column are coloured according to the actual genotype of the dog