Fig. 2
Reconstructed 3D images of the 2nd lumbar vertebrae also showing a noticeable difference in bone mass between the control (a) and treatment group (b). Similar to the distal femur, (c) bone volume (BV/TV), (d) trabecular number (Tb.N) and (e) volumetric bone mineral density (vBMD) were increased while (f) trabecular separation (Tb. Sp) was decreased in ActRIIB-Fc-treated mice compared to controls. ActRIIB-Fc and running did not result in further beneficial effect. # = p < 0.05 compared to PBS, * = p < 0.05 compared to PBS-R