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Table 3 Repartition of the study population in categories based on cut-off analysis

From: Effect of chondroitin sulfate on soluble biomarkers of osteoarthritis: a method to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients

From screening to baseline

(n = 63)

A

<−21 %

5 %

C

−21 % to +21 %

83 %

E

> + 21 %

13 %

From baseline to 1 month

(n = 63)

A

<−21 %

10 %

C

−21 % to +21 %

87 %

E

> + 21 %

3 %

From baseline to 3 months

(n = 60)

A

<−21 %

20 %

C

−21 % to +21 %

60 %

E

> + 21 %

20 %

From baseline to 6 months

(n = 53)

A

<−21 %

11 %

C

−21 % to +21 %

66 %

E

> + 21 %

23 %

  1. C = from −21 to +21 % (homeostasis); A = decrease in Coll2-1 catabolism >21 %; and E = Increase in Coll2-1 catabolism >21 %