Table 3 Area under the curve for ROC curves as well as slight or more, moderate or more and much better important difference for both the absolute and relative changes for the 6MWT
Important change | Max negative and positive changes in distancea | AUC (95 % CI) | Youden’s method | Sensitivity (95 % CI)b | Specificity (95 % CI)b | 80 % Specificity method | Sensitivity (95 % CI)b | Specificity (95 % CI)b |
|---|---|---|---|---|---|---|---|---|
10 weeks Absolute | ||||||||
Slight or more (n = 140) | −148.0 m to 290.0 m | 70.1 % (55.58, 84.7) | 11.5 m | 70.2 (62.41, 78.39) | 66.7 (40, 86.67) | 53.0 m | 48.9 (41.13, 57.45) | 80.0 (60, 100) |
Moderate or more (n = 128) | −148.0 m to 290.0 m | 72.3 % (51.15, 83.35) | 11.5 m | 74.4 (66.67, 82.95) | 70.4 (51.85, 85.19) | 53.0 m | 51.9 (42.64, 60.47) | 81.4 (66.67, 92.59) |
Much better (n = 85) | −148.0 m to 252.0 m | 62.8 % (53.85, 71.78) | 11.5 m | 79.1 (70.93, 87.21) | 48.6 (36.39, 60) | 106.5 m | 29.1 (19.16, 38.37) | 80.0 (71.43, 88.57) |
10 weeks Relative | ||||||||
Slight or more (n = 140) | −92.6 to 486.0 % | 67.3 % (51.21, 83.44) | 5.1 % | 66.7 (58.16, 74.13) | 66.7 (40, 86.67) | 15.1 % | 49.7 (40.43, 58.16) | 80.0 (60, 100) |
Moderate or more (n = 128) | −92.6 to 486.0 % | 70.7 % (59.05, 82.32) | 5.1 % | 70.5 (62.02, 78.29) | 70.4 (51.85, 85.19) | 15.5 % | 48.8 (40.31, 56.59) | 81.5 (66.67, 94.54) |
Much better (n = 85) | −92.6 to 486.0 % | 60.7 % (51.53, 69.9) | 5.7 % | 54.3 (44.29, 65.71) | 70.5 (63.95, 83.17) | 49.1 % | 23.3 (15.12, 32.56) | 80.0 (70.68, 88.57) |
26 weeks Absolute | ||||||||
Slight or more (n = 188) | −242.3 m to 370.0 m | 72.4 % (62.05, 82.7) | 26 m | 72.9 (66.21, 79.26) | 65.2 (45.54, 82.61) | 64.5 m | 50.0 (43.09, 56.91) | 82.6 (67.28, 95.65) |
Moderate or more (n = 179) | −242.3 m to 370.0 m | 70.6 % (60.33, 80.94) | 6.5 m | 81.6 (75.98, 87.15) | 56.3 (38.98, 71.88) | 71.0 m | 48.0 (41.05, 55.31) | 81.3 (67.28, 95.65) |
Much better (n = 143) | −194.0 m to 370.0 m | 64.7 % (56.59, 72.77) | 8.5 m | 84.4 (78.01, 90.07) | 41.4 (31.43, 54.29) | 110.5 m | 35.5 (27.66, 43.63) | 81.4 (72.86, 90) |
26 weeks Relative | ||||||||
Slight or more (n = 188) | −93 to 515.2 % | 71.7 % (60.64, 82.79) | 11.3 % | 65.4 (58.51, 72.09) | 73.9 (56.52, 89.24) | 18.3 % | 52.1 (45.74, 59.04) | 82.6 (67.28, 95.65) |
Moderate or more (n = 179) | −93.2 to 515.2 % | 69.6 % (58.74, 80.4) | 1.5 % | 82.1 (76.54, 87.71) | 56.3 (37.5, 71.88) | 27.9 % | 40.78 (33.78, 48.6) | 81.3 (65.62, 93.75) |
Much better (n = 143) | −91.3 to 515.2 % | 63.4 % (55.07, 71.78) | 1.54 % | 85.1 (79.06, 90.78) | 41.4 (30, 52.86) | 61.0 % | 21.3 (14.18, 27.66) | 84.3 (74.29, 84.29) |