Table 4 Multivariable-adjusted logistic regression for predictors of higher than median SF36-Bodily Pain scores after 1 year in TNFα-inhibitor and non-biologic cohorts

Age

Tertiles

1.14 (1.06 - 1.22)

0.001

1.19 (1.12 - 1.27)

<0.001

1.06 (0.90 - 1.25)

0.470

1.03 (0.89 - 1.18)

0.728

Gender

Female

0.84 (0.73 - 0.96)

0.013

0.84 (0.74 - 0.94)

0.003

0.86 (0.65 - 1.14)

0.296

0.90 (0.71 - 1.15)

0.317

BMI

WHO groups

1.12 (1.05 - 1.21)

0.002

1.13 (1.05 - 1.21)

0.001

1.06 (0.91 - 1.24)

0.463

1.07 (0.93 - 1.22)

0.353

Smoking

Current

1.25 (1.07 - 1.46)

0.006

1.28 (1.11 - 1.47)

<0.001

0.98 (0.70 - 1.38)

0.924

1.16 (0.87 - 1.54)

0.317

Smoking

Ex-

1.03 (0.90 - 1.17)

0.678

1.05 (0.94 - 1.17)

0.421

1.14 (0.87 - 1.49)

0.344

1.16 (0.92 - 1.46)

0.698

DAS28

Tertiles

1.02 (0.95 - 1.10)

0.638

1.01 (0.95 - 1.08)

0.640

0.80 (0.68 - 0.94)

0.007

0.86 (0.75 - 0.99)

0.041

DAS28-P

Tertiles

1.13 (1.05 - 1.21)

0.001

1.14 (1.07 - 1.21)

<0.001

1.26 (1.08 - 1.47)

0.003

1.27 (1.11 - 1.46)

0.001

Duration

Tertiles

1.04 (0.97 - 1.12)

0.264

1.01 (0.95 - 1.08)

0.660

1.08 (0.92 - 1.27)

0.326

1.08 (0.94 - 1.24)

0.265

Serology

Positive

0.91 (0.81 - 1.03)

0.127

0.96 (0.86 - 1.07)

0.440

1.01 (0.79 - 1.30)

0.919

1.04 (0.84 - 1.29)

0.696

Erosions

Positive

0.93 (0.82 - 1.05)

0.244

0.94 (0.85 - 1.05)

0.282

0.98 (0.75 - 1.27)

0.848

1.02 (0.82 - 1.28)

0.838

Extra-articular manifestation

Yes

1.09 (0.96 - 1.23)

0.191

1.06 (0.95 - 1.18)

0.305

1.03 (0.77 - 1.39)

0.840

0.95 (0.74 - 1.22)

0.698

Co-morbidity

Yes

1.27 (1.12 - 1.43)

<0.001

1.29 (1.16 - 1.43)

<0.001

1.31 (1.01 - 1.70)

0.041

1.24 (1.00 - 1.55)

0.055

HAQ

Tertiles

0.98 (0.91 - 1.05)

0.553

0.99 (0.93 - 1.05)

0.703

1.44 (1.17 - 1.78)

<0.001

1.55 (1.29 - 1.87)

<0.001

SF36-Vitality

Tertiles

0.95 (0.88 1.03)

0.183

0.97 (0.91 - 1.04)

0.382

1.31 (1.10 - 1.55)

0.002

1.21 (1.04 - 1.40)

0.015

SF36-Mental Health

Tertiles

1.25 (1.17 - 1.35)

<0.001

1.23 (1.15 - 1.31)

<0.001

1.29 (1.08 - 1.53)

0.005

1.29 (1.11 - 1.50)

0.001

SF36-Physical Function

Tertiles

1.51 (1.40 - 1.63)

<0.001

1.47 (1.37 - 1.57)

<0.001

1.44 (1.18 - 1.76)

<0.001

1.36 (1.14 - 1.62)

<0.001

SF36-Bodily Pain

Tertiles

1.49 (1.38 - 1.62)

<0.001

1.46 (1.36 - 1.57)

<0.001

1.99 (1.64 - 2.42)

<0.001

1.77 (1.49 - 2.10)

<0.001

Steroid

At baseline

1.24 (1.09 - 1.40)

0.001

1.28 (1.15 - 1.43)

<0.001

1.25 (0.94 - 1.67)

0.124

1.35 (1.06 - 1.73)

0.016

Methotrexate

At baseline

0.80 (0.71 - 0.91)

0.001

0.81 (0.72 - 0.92)

<0.001

0.84 (0.61 - 1.14)

0.250

0.91 (0.70 - 1.19)

0.508

Sulphasalazine

At baseline

0.80 (0.68 - 0.94)

0.008

0.81 (0.70 - 0.93)

0.003

0.87 (0.65 - 1.16)

0.337

0.98 (0.76 - 1.25)

0.845

Lefunomide

At baseline

1.18 (0.97 - 1.44)

0.107

1.20 (1.01 - 1.43)

0.038

1.13 (0.73 - 1.74)

0.595

1.18 (0.81 - 1.71)

0.394

Azathioprine

At baseline

1.40 (1.02 - 1.93)

0.036

1.18 (0.89 - 1.56)

0.245

1.26 (0.49 - 3.24)

0.637

1.87 (0.83 - 4.19)

0.131

Hydroxychloroquine

At baseline

0.83 (0.68 - 1.01)

0.061

0.83 (0.70 - 0.99)

0.034

0.82 (0.59 - 1.15)

0.248

0.90 (0.68 - 1.20)

0.473

Gold

At baseline

0.93 (0.65 - 1.31)

0.664

1.03 (0.75 - 1.40)

0.858

1.20 (0.69 - 2.07)

0.523

1.22 (0.75 - 1.99)

0.428