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Table 1 Characteristics of the datasets included in meta-analysis on association between LBX1 polymorphisms and AIS

From: Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects

First author Year Country Ethnicity Case number (all cases, male/female) Control number (all controls, male/female) Cobb angles degrees of the included patients Genotyping method Quality grade SNP tested and included in meta-analysis
Chettier et al. 2015 USA Caucasian 620 female cases 1287 female controls More than 10 degrees Affymetrix HuSNP 6.0 Microarray A (scored 15) rs111090870, rs678741
Fan et al. 2012 China Asian 300, 52/248 788, 299/489 More than 35 degrees PCR-based invader assay A (scored 18) rs111090870
Gao et al. 2013 China Asian 513, 66/447 440, 151/289 25.57 ± 14.10 degrees PCR-MassArray assay A (scored 16) rs111090870, rs11598564, rs625039
Grauers et al. 2015 Sweden and Denmark Caucasian 1739, 241/1498 1812, 0/1812 38.8 ± 17.5 degrees MassArray assay A (scored 15) rs111090870
Jiang et al. 2013 China Asian 949, 129/820 976, 314/662 More than 20 degrees PCR-based invader assay A (scored 15) rs111090870
Liu 2015 China Asian 180, 29/151 182, 30/152 NA PCR-MassArray assay A (scored 17) rs111090870, rs625039
Takahashi et al. 2012 Japan Asian 1453, 94/1359 13127, 1849/11278 More than15 degrees I PCR-based invader assay, llumina Human610 and HumanHap550v3 microarrays A (scored 20) rs111090870, rs11598564, rs625039
Zhu et al. 2015 China Asian 4317 female cases 6016 female controls 37.2 ± 9.4 degrees Affymetrix Genome-wide Human SNP array 6.0 A (scored 15) rs678741
  1. AIS adolescent idiopathic scoliosis; GWAS genome-wide association; USA United States of America; PCR polymorphism chain reaction; SNP single nucleotide polymorphism, NA not applicable
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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