Table 1 Characteristics of the datasets included in meta-analysis on association between LBX1 polymorphisms and AIS
First author | Year | Country | Ethnicity | Case number (all cases, male/female) | Control number (all controls, male/female) | Cobb angles degrees of the included patients | Genotyping method | Quality grade | SNP tested and included in meta-analysis |
|---|---|---|---|---|---|---|---|---|---|
Chettier et al. | 2015 | USA | Caucasian | 620 female cases | 1287 female controls | More than 10 degrees | Affymetrix HuSNP 6.0 Microarray | A (scored 15) | rs111090870, rs678741 |
Fan et al. | 2012 | China | Asian | 300, 52/248 | 788, 299/489 | More than 35 degrees | PCR-based invader assay | A (scored 18) | rs111090870 |
Gao et al. | 2013 | China | Asian | 513, 66/447 | 440, 151/289 | 25.57 ± 14.10 degrees | PCR-MassArray assay | A (scored 16) | rs111090870, rs11598564, rs625039 |
Grauers et al. | 2015 | Sweden and Denmark | Caucasian | 1739, 241/1498 | 1812, 0/1812 | 38.8 ± 17.5 degrees | MassArray assay | A (scored 15) | rs111090870 |
Jiang et al. | 2013 | China | Asian | 949, 129/820 | 976, 314/662 | More than 20 degrees | PCR-based invader assay | A (scored 15) | rs111090870 |
Liu | 2015 | China | Asian | 180, 29/151 | 182, 30/152 | NA | PCR-MassArray assay | A (scored 17) | rs111090870, rs625039 |
Takahashi et al. | 2012 | Japan | Asian | 1453, 94/1359 | 13127, 1849/11278 | More than15 degrees | I PCR-based invader assay, llumina Human610 and HumanHap550v3 microarrays | A (scored 20) | rs111090870, rs11598564, rs625039 |
Zhu et al. | 2015 | China | Asian | 4317 female cases | 6016 female controls | 37.2 ± 9.4 degrees | Affymetrix Genome-wide Human SNP array 6.0 | A (scored 15) | rs678741 |