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Table 1 Treatment sequences

From: Safety and pharmacodynamic dose response of short-term prednisone in healthy adult subjects: a dose ranging, randomized, placebo-controlled, crossover study

Treatment sequence Subjects, n Treatment period
1 2 3
A 5 Placebo 2.5 mg 10 mg
B 5 2.5 mg 5 mg 20 mg
C 5 5 mg 10 mg 40 mg
D 5 10 mg 20 mg 60 mg
E 5 20 mg 40 mg Placebo
F 5 40 mg 60 mg 2.5 mg
G 5 60 mg Placebo 5 mg
Total 35a  
  1. Doses shown correspond to the daily prednisone dose administered for 7 days in each treatment period
  2. aTwo subjects discontinued the study during Period 2 and were replaced following approval by the study statistician