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Table 1 Treatment sequences

From: Safety and pharmacodynamic dose response of short-term prednisone in healthy adult subjects: a dose ranging, randomized, placebo-controlled, crossover study

Treatment sequence

Subjects, n

Treatment period

1

2

3

A

5

Placebo

2.5 mg

10 mg

B

5

2.5 mg

5 mg

20 mg

C

5

5 mg

10 mg

40 mg

D

5

10 mg

20 mg

60 mg

E

5

20 mg

40 mg

Placebo

F

5

40 mg

60 mg

2.5 mg

G

5

60 mg

Placebo

5 mg

Total

35a

 
  1. Doses shown correspond to the daily prednisone dose administered for 7 days in each treatment period
  2. aTwo subjects discontinued the study during Period 2 and were replaced following approval by the study statistician
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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