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Table 2 Cartilage morphology and bone marrow lesion ─ baseline and change from baseline to 12 months

From: Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial

   Cartilage morphology Bone marrow lesion
   100 μg cohort (n = 57)
mean (95 % CI)
Matched placebo (n = 18)
mean (95 % CI)
p - value 100 μg cohort (n = 56)
mean (95 % CI)
Matched placebo (n = 18)
mean (95 % CI)
p - value
Whole knee Baseline 21.1 (17.2, 25.0) 30.0 (22.0,37.9) 0.040* 3.3 (2.5, 4.1) 3.3 (1.4, 5.2) 0.642
  Delta sum 0.42 (0.00, 0.84) 0.94 (−0.34, 2.23) 0.362 −0.20 (−0.67, 0.28) 0.22 (−0.62, 1.07) 0.237
  Delta subregion 0.19 (−0.01, 0.40) 0.44 (−0.24, 1.13) 0.371 −0.23 (−0.60, 0.14) 0.22 (−0.43, 0.87) 0.113
LTFJ Baseline 4.5 (2.6, 6.4) 7.6 (3.8, 11.5) 0.019* 0.7 (0.3, 1.1) 0.7 (0.0, 1.4) 0.981
  Delta sum 0.07 (−0.16, 0.30) 0.17 (−0.09, 0.42) 0.342 0.04 (−0.16, 0.23) 0.11 (−0.05, 0.27) 0.242
  Delta subregion 0.05 (−0.07, 0.18) 0.11 (−0.05, 0.27) 0.349 0.04 (−0.13, 0.20) 0.17 (−0.02, 0.36) 0.107
MTFJ Baseline 9.3 (7.2, 11.5) 11.5 (7.3, 15.8) 0.352 1.6 (1.1, 2.2) 1.1 (0.3, 1.9) 0.418
  Delta sum 0.30 (−0.04, 0.64) 0.33 (−0.28, 0.95) 0.690 −0.11 (−0.50, 0.28) 0.11 (−0.52, 0.75) 0.469
  Delta subregion 0.12 (−0.03, 0.27) 0.11 (−0.27, 0.49) 0.712 −0.13 (−0.40, 0.15) 0.06 (−0.34, 0.45) 0.510
PFJ Baseline 7.3 (5.6., 9.1) 10.8 (7.5, 14.1) 0.038* 1.0 (0.5, 1.5) 1.5 (0.1, 2.9) 1.000
  Delta sum 0.05 (−0.06, 0.17) 0.44 (−0.18, 1.06) 0.048* −0.13 (−0.34, 0.09) 0.00 (−0.38, 0.38) 0.368
  Delta subregion 0.02 (−0.04, 0.08) 0.22 (−0.05, 0.49) 0.046* −0.14 (−0.34, 0.06) 0.00 (−0.38, 0.38) 0.352
  1. CI confidence interval, LTFJ lateral tibio-femoral joint (includes 5 subregions), MTFJ medial tibio-femoral joint (includes 5 subregions), PFJ patello-femoral joint (includes 4 subregions). Possible score range for each subregion at baseline and 12-month is 0–3 and 0–6 for bone marrow lesion and cartilage morphology, respectively
  2. *Statistically significant at p ≤ 0.05