Table 2 Cartilage morphology and bone marrow lesion ─ baseline and change from baseline to 12 months
Cartilage morphology | Bone marrow lesion | ||||||
|---|---|---|---|---|---|---|---|
100 μg cohort (n = 57) mean (95 % CI) | Matched placebo (n = 18) mean (95 % CI) | p - value | 100 μg cohort (n = 56) mean (95 % CI) | Matched placebo (n = 18) mean (95 % CI) | p - value | ||
Whole knee | Baseline | 21.1 (17.2, 25.0) | 30.0 (22.0,37.9) | 0.040* | 3.3 (2.5, 4.1) | 3.3 (1.4, 5.2) | 0.642 |
Delta sum | 0.42 (0.00, 0.84) | 0.94 (−0.34, 2.23) | 0.362 | −0.20 (−0.67, 0.28) | 0.22 (−0.62, 1.07) | 0.237 | |
Delta subregion | 0.19 (−0.01, 0.40) | 0.44 (−0.24, 1.13) | 0.371 | −0.23 (−0.60, 0.14) | 0.22 (−0.43, 0.87) | 0.113 | |
LTFJ | Baseline | 4.5 (2.6, 6.4) | 7.6 (3.8, 11.5) | 0.019* | 0.7 (0.3, 1.1) | 0.7 (0.0, 1.4) | 0.981 |
Delta sum | 0.07 (−0.16, 0.30) | 0.17 (−0.09, 0.42) | 0.342 | 0.04 (−0.16, 0.23) | 0.11 (−0.05, 0.27) | 0.242 | |
Delta subregion | 0.05 (−0.07, 0.18) | 0.11 (−0.05, 0.27) | 0.349 | 0.04 (−0.13, 0.20) | 0.17 (−0.02, 0.36) | 0.107 | |
MTFJ | Baseline | 9.3 (7.2, 11.5) | 11.5 (7.3, 15.8) | 0.352 | 1.6 (1.1, 2.2) | 1.1 (0.3, 1.9) | 0.418 |
Delta sum | 0.30 (−0.04, 0.64) | 0.33 (−0.28, 0.95) | 0.690 | −0.11 (−0.50, 0.28) | 0.11 (−0.52, 0.75) | 0.469 | |
Delta subregion | 0.12 (−0.03, 0.27) | 0.11 (−0.27, 0.49) | 0.712 | −0.13 (−0.40, 0.15) | 0.06 (−0.34, 0.45) | 0.510 | |
PFJ | Baseline | 7.3 (5.6., 9.1) | 10.8 (7.5, 14.1) | 0.038* | 1.0 (0.5, 1.5) | 1.5 (0.1, 2.9) | 1.000 |
Delta sum | 0.05 (−0.06, 0.17) | 0.44 (−0.18, 1.06) | 0.048* | −0.13 (−0.34, 0.09) | 0.00 (−0.38, 0.38) | 0.368 | |
Delta subregion | 0.02 (−0.04, 0.08) | 0.22 (−0.05, 0.49) | 0.046* | −0.14 (−0.34, 0.06) | 0.00 (−0.38, 0.38) | 0.352 | |