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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

Fig. 1

Comparative analyses of Padi4−/− and wild-type mouse models of experimental arthritis. Wild-type (n = 10) and Padi4−/− (n = 7) mice were immunized with bovine type II collagen (CII) and boosted on day 21 (arrowheads). As control mice, Wild-type (n = 5), and Padi4−/− mice (n = 5) were immunized with PBS. a Arthritis severity score. The severity of arthritis was graded according to the scale defined in Materials and Methods. The data are presented as the mean clinical score ± SEM. *P < 0.05 (U-test). b Incidence of arthritis. The percentage of affected animals in each group was determined on each day. The IgM isotype (c) and IgG isotype (d) of anti-CII antibodies in the wild-type and Padi4−/− mice sera before and after injection, as determined by ELISA. * P < 0.05, **P < 0.01 (Student’s t-test)

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