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Table 6 Time-varying Cox regression analysis of association between GI events and treatment initiation
| Effect | Estimated hazard ratio | 95 % CI | p value |
|---|---|---|---|
| Post-index GI event (ref: no post-index GI event) | 0.243 | (0.22, 0.27) | <0.0001 |
| Age group | |||
| 65–74 vs. 55–64 | 1.274 | (1.16, 1.40) | <0.0001 |
| 75–84 vs. 55–64 | 1.444 | (1.31, 1.60) | <0.0001 |
| 85+ vs. 55–64 | 1.234 | (1.06, 1.43) | 0.0023 |
| Pre-index medication use | |||
| Gastro-protective agents | 1.621 | (1.52, 1.79) | <0.0001 |
| NSAIDs | 1.287 | (1.20, 1.38) | <0.0001 |
| Glucocorticoids | 1.223 | (1.14, 1.68) | <0.0001 |
| Charlson comorbidity index score | 0.913 | (0.85, 0.98) | 0.0034 |
