|
Effect
|
Estimated hazard ratio
|
95 % CI
|
p value
|
|---|
|
Post-index GI event (ref: no post-index GI event)
|
0.243
|
(0.22, 0.27)
|
<0.0001
|
|
Age group
| | | |
|
65–74 vs. 55–64
|
1.274
|
(1.16, 1.40)
|
<0.0001
|
|
75–84 vs. 55–64
|
1.444
|
(1.31, 1.60)
|
<0.0001
|
|
85+ vs. 55–64
|
1.234
|
(1.06, 1.43)
|
0.0023
|
|
Pre-index medication use
| | | |
|
Gastro-protective agents
|
1.621
|
(1.52, 1.79)
|
<0.0001
|
|
NSAIDs
|
1.287
|
(1.20, 1.38)
|
<0.0001
|
|
Glucocorticoids
|
1.223
|
(1.14, 1.68)
|
<0.0001
|
|
Charlson comorbidity index score
|
0.913
|
(0.85, 0.98)
|
0.0034
|
-
GI gastrointestinal, NSAIDs non-steroidal anti-inflammatory drugs
-
CI confidence interval
