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Table 6 Time-varying Cox regression analysis of association between GI events and treatment initiation

From: Association between gastrointestinal events and osteoporosis treatment initiation in women diagnosed with osteoporosis in France: a retrospective analysis

Effect Estimated hazard ratio 95 % CI p value
Post-index GI event (ref: no post-index GI event) 0.243 (0.22, 0.27) <0.0001
Age group    
 65–74 vs. 55–64 1.274 (1.16, 1.40) <0.0001
 75–84 vs. 55–64 1.444 (1.31, 1.60) <0.0001
 85+ vs. 55–64 1.234 (1.06, 1.43) 0.0023
Pre-index medication use    
 Gastro-protective agents 1.621 (1.52, 1.79) <0.0001
 NSAIDs 1.287 (1.20, 1.38) <0.0001
 Glucocorticoids 1.223 (1.14, 1.68) <0.0001
Charlson comorbidity index score 0.913 (0.85, 0.98) 0.0034
  1. GI gastrointestinal, NSAIDs non-steroidal anti-inflammatory drugs
  2. CI confidence interval