|
Effect
|
Initiated any treatment vs. no treatment initiated
|
|---|
|
Post-index GI event (ref: no post-index GI event)
|
Odds ratio
|
95 % CI
|
p value
|
|---|
|
Among patients without pre-index GI problems
|
0.293
|
(0.25, 0.34)
|
<0.0001
|
|
Among patients with pre-index GI problems
|
0.257
|
(0.20, 0.31)
|
<0.0001
|
|
Age group
| | | |
|
65–74 vs. 55–64
|
1.319
|
(1.14, 1.47)
|
0.0024
|
|
75–84 vs. 55–64
|
1.538
|
(1.26, 1.72)
|
<0.0001
|
|
85+ vs. 55–64
|
1.271
|
(1.05, 1.63)
|
0.1432
|
|
Pre-index medication use
| | | |
|
Gastro-protective agents
|
1.755
|
(1.58, 1.95)
|
<0.0001
|
|
NSAIDs
|
1.337
|
(1.23, 1.45)
|
<0.0001
|
|
Glucocorticoids
|
1.254
|
(1.13, 1.39)
|
<0.0001
|
|
Charlson comorbidity index score
|
0.929
|
(0.89, 0.97)
|
0.0093
|
-
GI gastrointestinal, NSAIDs non-steroidal anti-inflammatory drugs
-
CI confidence interval
