Fig. 2
From: Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis
Agarose gel electrophoresis of aggrecan from different individuals. Proteoglycan from guanidine extracts of OA articular cartilage were analyzed by electrophoresis on agarose gels. Aggrecan was visualized by staining the gel with Toluidine blue. Cartilage samples were obtained midway between the lesion and the joint margin from the femoral condyles. Representative samples from eight individuals (M3-M10) are shown. The migration position of isolated chondroitin sulfate chains, indicated as CS, is included to demark the migration position of the smallest possible proteolytic cleavage product