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Table 2 The results of meta-analysis and subgroup analysis

From: The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis

Outcomes No. studies No. Patients SMD or OR (95 % CI) P value Heterogeneity
IA TXA IV TXA
Total blood loss 10 642 635 −297.65 (−371.60 to −223.69) <0.01 I2 = 71 %
 RCT 5 281 247 −378.96 (−454.12 to −303.81) <0.01 I2 = 18 %
 nRCT 5 102 101 −218.88 (−271.68 to −166.08) <0.01 I2 = 30 %
Total drain out 6 363 428 −164.68 (−236.63 to −92.73) <0.01 I2 = 96 %
 RCT 4 179 164 −187.97 (−276.77 to −99.18) <0.01 I2 = 93 %
 nRCT 2 184 284 −121.95 (−318.92 to 75.03) 0.22 I2 = 99 %
Transfusion rates 12 871 1893 0.29 (0.19 to 0.44) <0.01 I2 = 46 %
 RCT 5 319 304 0.21 (0.13 to 0.34) <0.01 I2 = 0 %
 nRCT 7 552 1589 0.36 (0.19 to 0.66) <0.01 I2 = 59 %
 Hb drop 11 774 822 −0.66 (−0.91 to −0.41) <0.01 I2 = 81 %
 RCT 5 292 280 −0.72 (−1.24 to −0.19) <0.01 I2 = 88 %
 nRCT 6 482 542 −0.61 (−0.87 to −0.36) <0.01 I2 = 71 %
Length of hospital stay 6 542 602 −0.40 (−0.91 to 0.11) 0.13 I2 = 83 %
 RCT 2 181 180 −0.27 (−1.29 to 0.75) 0.60 I2 = 66 %
 nRCT 4 361 422 −0.51 (−1.37 to 0.35) 0.24 I2 = 88 %
 DVTs 6 348 1355 1.19 (0.40 to 3.57) 0.75 I2 = 0 %
 RCT 3 162 160 1.28 (0.31 to 5.29) 0.73 I2 = 0 %
 nRCT 3 186 1195 1.07 (0.19 to 6.12) 0.94 I2 = 0 %
 PE 2 224 1281 1.11 (0.11 to 10.81) 0.93 I2 = 6 %
 nRCT 2 224 1281 1.11 (0.11 to 10.81) 0.93 I2 = 6 %
  1. Hb hemoglobin, DVT deep venous thrombosis, PE pulmonary embolism