Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study

Hall, Joanna; Laslett, Laura L.; Martel-Pelletier, Johanne; Pelletier, Jean-Pierre; Abram, François; Ding, Chang-Hai; Cicuttini, Flavia M.; Jones, Graeme

doi:10.1186/s12891-016-0879-0

Table 2 Association between change in cartilage volume, and new or worsening meniscal extrusions, meniscal tears, and cartilage defects over 2.4 years; and change in joint space width over 5 years

From: Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study

Population	Change in..	Medial joint space width		Lateral joint space width
		Univariable	Multivariable^a	Univariable	Multivariable^a
All participants	Tibial + femoral cartilage volume	R²4.4 %, p = 0.009	R² 2.2 %, p = 0.064	R²4.9 %, p = 0.006	R²4.8 %, p = 0.007
(n = 151 medially,	Meniscal extrusion	R²4.3 %, p = 0.01	R² 2.4 %, p = 0.053	NA	NA
n = 150 laterally)	Meniscal tears	R² 0.19 %, p = 0.60	R² 0.0 %, p = 0.97	R² 1.4 %, p = 0.15	R² 1.2 %, p = 0.18
	Cartilage defects (tibia + femur)	R² 1.4 %, p = 0.15	R² 0.7 %, p = 0.29	R² 0.26 %, p = 0.54	R² 0.01 %, p = 0.90
			Total R² 7.7 %		Total R² 6.2 %
Subgroup: cartilage measurement site
Tibia	Tibial cartilage volume	R² 1.7 %, p = 0.11	R² 0.8 %, p = 0.26	R² 3.34 %, p = 0.024	R²3.8 %, p = 0.017
(n = 151)	Meniscal extrusion	R²4.3 %, p = 0.01	R²3.1 %, p = 0.031	NA	NA
	Meniscal tears	R² 0.19 %, p = 0.60	R² 0.01 %, p = 0.91	R² 1.35 %, p = 0.15	R² 1.3 %, p = 0.16
	Tibial cartilage defects	R² 0.23 %, p = 0.56	R² 0.02 %, p = 0.85	R² 0.03 %, p = 0.83	R² 0.3 %, p = 0.52
			Total R² 5.1 %		Total R² 5.1 %
Femur	Femoral cartilage volume	R²3.8 %, p = 0.016	R² 1.8 %, p = 0.095	R² 1.72 %, p = 0.11	R² 1.5 %, p = 0.13
(n = 150)	Meniscal extrusion	R²4.3 %, p = 0.01	R²3.2 %, p = 0.024	NA	NA
	Meniscal tears	R² 0.19 %, p = 0.6	R² 0.04 %, p = 0.80	R² 1.35 %, p = 0.15	R² 1.2 %, p = 0.19
	Femoral cartilage defects	R²3.0 %, p = 0.035	R² 2.2 %, p = 0.063	R² 2.26 %, p = 0.07	R² 2.2 %, p = 0.07
			Total R² 9.0 %		Total R² 4.9 %
Subgroup: Radiographic OA of OARSI grade ≥1 (n = 85)	Tibial + femoral cartilage volume	R²7.8 %, p = 0.01	R² 2.1 %, p = 0.16	R² 3.0 %, p = 0.11	R² 3.3 %, p = 0.096
	Meniscal extrusion	R²11.2 %, p = 0.002	R²6.2 %, p = 0.017	NA	NA
	Meniscal tears	R² 0.02 %, p = 0.91	R² 0.4 %, p = 0.53	R² 1.38 %, p = 0.28	R² 1.9 %, p = 0.21
	Tibial + femoral cartilage defects	R² 4.5 %, p = 0.051	R² 2.3 %, p = 0.14	R² 0.49 %, p = 0.53	R² 1.1 %, p = 0.33
			Total R² 16.7 %		Total R² 5.6 %

Results obtained using linear regression
^aAdjusted for change in cartilage volume, change in meniscal extrusion, change in meniscal tears or change in cartilage defects where applicable
NA indicates not applicable (incidence of meniscal extrusion very low)
Bold text indicates statistically significant result (p ≤ 0.05)
R² for univariable models is the proportion of variance explained provided (R²) for the linear regression
R² for multivariable models is the proportion of variance explained for individual components of the multivariable model (semipartial R²)
Total R² is the proportion of variance explained for the entire multivariable model

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