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Table 2 Association between change in cartilage volume, and new or worsening meniscal extrusions, meniscal tears, and cartilage defects over 2.4 years; and change in joint space width over 5 years

From: Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study

Population Change in.. Medial joint space width Lateral joint space width
   Univariable Multivariablea Univariable Multivariablea
All participants Tibial + femoral cartilage volume R24.4 %, p= 0.009 R2 2.2 %, p = 0.064 R24.9 %, p= 0.006 R24.8 %, p= 0.007
(n = 151 medially, Meniscal extrusion R24.3 %, p= 0.01 R2 2.4 %, p = 0.053 NA NA
n = 150 laterally) Meniscal tears R2 0.19 %, p = 0.60 R2 0.0 %, p = 0.97 R2 1.4 %, p = 0.15 R2 1.2 %, p = 0.18
  Cartilage defects (tibia + femur) R2 1.4 %, p = 0.15 R2 0.7 %, p = 0.29 R2 0.26 %, p = 0.54 R2 0.01 %, p = 0.90
    Total R2 7.7 %   Total R2 6.2 %
Subgroup: cartilage measurement site
Tibia Tibial cartilage volume R2 1.7 %, p = 0.11 R2 0.8 %, p = 0.26 R2 3.34 %, p = 0.024 R23.8 %, p= 0.017
(n = 151) Meniscal extrusion R24.3 %, p= 0.01 R23.1 %, p= 0.031 NA NA
  Meniscal tears R2 0.19 %, p = 0.60 R2 0.01 %, p = 0.91 R2 1.35 %, p = 0.15 R2 1.3 %, p = 0.16
  Tibial cartilage defects R2 0.23 %, p = 0.56 R2 0.02 %, p = 0.85 R2 0.03 %, p = 0.83 R2 0.3 %, p = 0.52
    Total R2 5.1 %   Total R2 5.1 %
Femur Femoral cartilage volume R23.8 %, p= 0.016 R2 1.8 %, p = 0.095 R2 1.72 %, p = 0.11 R2 1.5 %, p = 0.13
(n = 150) Meniscal extrusion R24.3 %, p= 0.01 R23.2 %, p= 0.024 NA NA
  Meniscal tears R2 0.19 %, p = 0.6 R2 0.04 %, p = 0.80 R2 1.35 %, p = 0.15 R2 1.2 %, p = 0.19
  Femoral cartilage defects R23.0 %, p= 0.035 R2 2.2 %, p = 0.063 R2 2.26 %, p = 0.07 R2 2.2 %, p = 0.07
    Total R2 9.0 %   Total R2 4.9 %
Subgroup:
Radiographic OA of OARSI grade ≥1 (n = 85)
Tibial + femoral cartilage volume R27.8 %, p= 0.01 R2 2.1 %, p = 0.16 R2 3.0 %, p = 0.11 R2 3.3 %, p = 0.096
Meniscal extrusion R211.2 %, p= 0.002 R26.2 %, p= 0.017 NA NA
Meniscal tears R2 0.02 %, p = 0.91 R2 0.4 %, p = 0.53 R2 1.38 %, p = 0.28 R2 1.9 %, p = 0.21
Tibial + femoral cartilage defects R2 4.5 %, p = 0.051 R2 2.3 %, p = 0.14 R2 0.49 %, p = 0.53 R2 1.1 %, p = 0.33
    Total R2 16.7 %   Total R2 5.6 %
  1. Results obtained using linear regression
  2. aAdjusted for change in cartilage volume, change in meniscal extrusion, change in meniscal tears or change in cartilage defects where applicable
  3. NA indicates not applicable (incidence of meniscal extrusion very low)
  4. Bold text indicates statistically significant result (p ≤ 0.05)
  5. R2 for univariable models is the proportion of variance explained provided (R2) for the linear regression
  6. R2 for multivariable models is the proportion of variance explained for individual components of the multivariable model (semipartial R2)
  7. Total R2 is the proportion of variance explained for the entire multivariable model