|
Comparison
|
Mean TA difference
|
95 % CI
|
P value
|
|---|
|
t1 vs. t2
|
2.8
|
−2.8 – 8.5
|
<0.0001
|
|
t1 vs. t3
|
4.5
|
−1.2 – 10.2
|
<0.0001
|
|
t1 vs. t4
|
4.9
|
−0.7 – 10.7
|
<0.0001
|
|
t1 vs. t5
|
3.8
|
−1.8 – 9.5
|
<0.0001
|
|
t2 vs. t3
|
1.6
|
−4.0 – 7.3
|
>0.05
|
|
t2 vs. t4
|
2.1
|
−3.6 – 7.8
|
<0.0001
|
|
t2 vs. t5
|
0.9
|
−4.7 – 6.6
|
>0.05
|
|
t3 vs. t4
|
0.4
|
−5.2 – 6.2
|
>0.05
|
|
t3 vs. t5
|
−0.6
|
−6.3 – 5.1
|
>0.05
|
|
t4 vs. t5
|
−1.1
|
−6.8 – 4.5
|
>0.05
|
- ANOVA indicates analysis of variance; CI, confidence interval; t1, beginning of treatment; t2, 1 year after the beginning of treatment; t3, intermediate time between t1 and t4; t4, end of weaning; t5, 2-year minimum follow-up from t4
