Fig. 5

longitudinal μCT sections of femurs at 3, 7, 14, and 42 days for the control (saline) and infected (10⁷ CFU S. aureus injected via tail vein) and longitudinal histological sections of bacterial colonization at 42 days post inoculation (stained with H&E) (a) progression of morphological changes within the bone between 3 and 42 days post inoculation as seen by μCT. Comparing the control and the infected limbs, the infection is evident by the periosteal reaction seen progressing (arrow) forming an involucrum (arrowhead). By 42 days, large amounts of boney remodeling are obvious in the infected bone compared to the control (*). b 42 days post inoculation with 10⁷ CFU S. aureus. The femoral condyle shows signs of bone remodeling