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Table 4 Literature data on correlation coefficients (with p values) between serum osteoprotegerin levels in men and the studied parameters

From: Cystatin C as a potential predictor of osteoprotegerin levels in healthy men, a cross-sectional, observational study

Authors

Age

BMD

T

E2

FEI

FTI

PTH

25-OH-D

Creatinine

Bone markers

Szulc et al. [7]

r = 0.41

n.s.

n.s.

n.s.

ar = 0.18

ar = 0.31

r = −0.23

n.s.

n.s.

br = −0.20 p < 0.01

p = 0.0001

p < 0.02

p = 0.0001

p < 0.01

Khosla et al. [8]

r = 0.39

cr = −0.17

r = −0.16

n.s.

dn.s.

er = −0.27

-

-

-

fr = 0.16 p < 0.05

p < 0.001

p < 0.05

p < 0.05

p < 0.001

gr = 0.26 p < 0.001

Khosla et al. [9]

-

-

-

-

-

-

-

-

-

hn.s.

Kudlacek et al. [10]

ip < 0.05

n.s.

r = 0.1

-

-

-

r = −0.17 p < 0.0001

n.s.

-

-

p < 0.05

Trofimov et al. [12]

r = 0.42

n.s.

n.s.

n.s.

-

-

-

-

-

-

p < 0.001

Oh et al. [13]

n.s.

jr = −0.259

n.s.

r = −0.319

-

-

-

-

-

kr = −0.25 p = 0.024

p = 0.020

p =0.004

Indridason et al. [14]

ip < 0.05

lr = −0.13 p ≤ 0.05

-

-

nr = 0.15

or = 0.09 p ≤ 0.001

n.s.

n.s.

p-

qr = −0.09 p ≤ 0.05

mr = −0.11 p ≤ 0.05

p ≤ 0.05

Mazziotti et al. [15]

r = 0.37 p = 0.002

-

-

-

-

-

-

-

rr = 0.46

sr = 0.47 p ≤ 0.05

p ≤ 0.05

Stern et al. [16]

r = 0.552

tp < 0.05

-

-

-

-

-

-

-

-

p < 0.001

Samelson et al. [17]

up < 0.05

vn.s.

-

-

-

-

-

-

wp < 0.05

-

Jorgensen et al. [18]

r = 0.52

xp = 0.001

-

-

-

-

-

-

-

-

p < 0.001

Szulc et al. [19]

-

yr = −0.28

-

-

-

-

-

-

-

zr = −0.10 p < 0.05

p < 0.001

aar = 0.25 p < 0.001

abr = 0.14 p < 0.05

This study

r = 0.359 p < 0.001

n.s.

n.s.

r = 0.16 p = 0.028

n.s.

r = −0.23 p = 0.001

n.s.

n.s.

acn.s.

n.s.

  1. BMD bone mineral density, T testosterone, E2 17β-estradiol, FEI free estradiol index, FTI free testosterone index, PTH parathyroid hormone, 25-OH-D 25-hydroxyvitamin D, n.s. statistically non significant
  2. aAfter adjustment for age and body weight in > 40 years of age, burinary total deoxypyridinoline (DPD) after adjustment for age in > 40 years of age, cmid-radius in ≥ 50 years of age, dr = −0.18 (p < 0.05) for bioavailable E2 in ≥ 50 years of age, er = −0.27 (p < 0.001) for bioavailable T in ≥ 50 years of age, furinary N-telopeptide of type I collagen (NTx), gurinary free DPD, hurinary NTx and DPD, istatistically significant positive correlation, but r value is not mentioned, jlumbal spine (LS), kosteocalcin (OC), ltotal body, mhip, n,ocalulated free sex hormone levels, pn.s. for cystatin C, qserum C-terminal cross-linked telopeptides of type I collagen (CTx), rin a group including men and women (n = 52) aged between 65 and 84 years, sserum CTx in a group including men and women (n = 52) aged between 65 and 84 years, tLS (statistically significant positive correlation, but r value is not mentioned), uage increased (Trend, p < 0.05) with increasing quartile of osteoprotegerin (OPG), vage-adjusted femur neck BMD showed no difference between OPG quartiles, wglomerular filtration rate (GFR) decreased (Trend, p < 0.05) with increasing quartile of OPG, xage-adjusted distal forearm BMD decreased (Trend, p = 0.001) with increasing OPG tertile, ytotal (distal radius and tibia) vBMD above the median OPG level, zOC and N-terminal extension type 1 collagen propeptide (P1NP) below the median OPG level, aaurinary DPD and abserum CTx above the median OPG level, acn.s. with creatinine and GFR but r = 0.298 (p < 0.001) with cystatin C
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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