Cystatin C as a potential predictor of osteoprotegerin levels in healthy men, a cross-sectional, observational study

Table 2 Spearman’s correlation analysis between serum osteoprotegerin and the studied variables

	All men (n = 194)		Middle-aged men (≤59 years of age, n = 98)		Older men (>59 years of age, n = 96)
	r	p	r	p	r	p
Age	0.359	<0.001	0.165	0.105	0.050	0.631
Body mass index	0.031	0.672	0.057	0.580	−0.036	0.725
sRANKL	−0.034	0.713	0.019	0.885	−0.038	0.774
sRANKL/Osteoprotegerin ratio	−0.234	0.010	−0.204	0.116	−0.199	0.131
Total 17-β-Estradiol	0.160	0.028	0.164	0.110	0.211	0.043
Total testosterone	−0.025	0.729	0.106	0.302	−0.064	0.540
Sex hormone binding globulin	0.070	0.342	0.199	0.052	0.060	0.568
Free Estradiol Index	−0.072	0.323	−0.084	0.414	0.048	0.648
Free testosterone Index	−0.230	0.001	−0.142	0.167	−0.169	0.106
Parathyroid hormone	−0.076	0.300	−0.172	0.093	−0.009	0.930
25-hydroxy-vitamin D	−0.123	0.091	−0.115	0.085	−0.030	0.774
Osteocalcin	−0.102	0.161	−0.037	0.717	−0.040	0.706
C-terminal telopeptides of type-I collagen	−0.100	0.171	−0.095	0.358	−0.053	0.611
PINP	−0.043	0.553	−0.006	0.951	−0.044	0.667
L1-L4 bone mineral density	0.026	0.716	−0.041	0.689	0.010	0.923
Femur neck bone mineral density	−0.074	0.307	−0.071	0.485	−0.001	0.995
Cystatin C	0.298	<0.001	0.022	0.832	0.322	0.002
Creatinine	0.038	0.618	−0.085	0.415	0.132	0.239
MDRD-eGFR	−0.071	0.351	0.083	0.428	−0.142	0.207
Cystatin C-eGFR	−0.343	<0.001	−0.031	0.766	−0.335	0.001
Cystatin C and creatinine-eGFR	−0.231	0.003	0.023	0.834	−0.262	0.020

sRANKL Soluble receptor activator of nuclear factor – κB ligand, PINP Total procollagen type 1 amino-terminal propeptide

ISSN: 1471-2474