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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines

Fig. 5

Effect of α-MSH on TIMP-3 secretion (a) and gene expression (b) in IL-1β or TNF-α-stimulated chondrocytes. Human primary chondrocytes were incubated for 4 h at 37 °C with 10−6M α-MSH and further cultured for 40 h in the presence or absence of 10 ng/mL IL-1β or TNF-α. TIMP-3 concentration in the supernatans (a) and gene expression (b) were then measured. Data from 4 separate experiments (± S.E.M.) are shown. *P < 0.002 vs Medium; **p < 0.001 vs Medium; °p < 0.02 vs Medium; °°p < 0.002 vs Medium; §p < 0.05 vs IL-1β

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