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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines

Fig. 3

Effect of α-MSH on MMP-3 secretion (a) and gene expression (b) in IL-1β or TNF-α-stimulated chondrocytes. Human primary chondrocytes were incubated for 4 h at 37 °C with 10−6M α-MSH and further cultured for 40 h in the presence or absence of 10 ng/mL IL-1β or TNF-α. MMP-3 concentration in the supernatans (a) and gene expression (b) were then measured. Data from 4 separate experiments (± S.E.M.) are shown. *p < 0.0001 vs Medium; §p < 0.001 vs IL-1β; °p < 0.01 vs TNF-α; °°p < 0.001 vs TNF-α

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