Fig. 2

Fold changes in gene expression in the capsule of immobilized knee joints. After pre-processing signal intensities from the immobilization group, expression levels at 2, 4, 8, and 16 weeks were log 2 transformed and values compared to the log 2 transformed results at week 1 using the CAGED algorithm to cluster genes with similar profiles of expression. Eight expression clusters were identified and clusters 2 and 3 had median fold changes between −2 and 2 and were thus eliminated. For the remaining 6 clusters, cluster centers corresponding to log2 value over the time course of immobilization-induced knee joint contracture were plotted over the time-course