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Table 5 Changes in SDAI scores and circulating biomarkers, stratified by shared epitope (risk allele) status

From: Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis

Risk allele negative
Variable n Baseline 6 months P value
   Median IQR Median IQR  
SDAI 47 39.18 23.50 18.00 19.50 0.0001
CRP (μg/ml) 47 18.00 43.60 7.00 14.60 0.0002
ACPA (IU/ml) 40 331.90 1006.60 185.60 654.15 0.0032
IL-4 (pg/ml) 10 2.55 7.99 5.24 7.18 NS
IL-8 (pg/ml) 44 7.68 14.15 5.23 5.98 NS
IL-10 (pg/ml) 10 7.34 27.79 19.18 19.91 NS
G-CSF (pg/ml) 44 14.42 36.94 12.18 81.23 NS
VEGF (pg/ml) 44 130.52 512.22 92.22 148.07 NS
Risk allele positive
Variable n Baseline 6 months P value
   Median IQR Median IQR  
SDAI 68 40.04 22.12 16.00 16.52 0.0001
CRP (μg/ml) 68 17.50 38.70 10.10 17.50 0.0005
ACPA (IU/ml) 56 561.10 911.05 277.60 677.80 0.0001
IL-4 (pg/ml) 19 5.00 9.80 1.00 1.50 0.0007
IL-8 (pg/ml) 65 9.49 12.15 5.97 6.20 0.0001
IL-10 (pg/ml) 19 11.24 18.78 5.53 6.52 0.0440
G-CSF (pg/ml) 65 8.66 42.11 1.85 24.74 0.0442
VEGF (pg/ml) 65 190.43 401.81 95.76 160.99 0.0056