Table 5 Changes in SDAI scores and circulating biomarkers, stratified by shared epitope (risk allele) status
Risk allele negative | ||||||
|---|---|---|---|---|---|---|
Variable | n | Baseline | 6 months | P value | ||
| Â | Â | Median | IQR | Median | IQR | Â |
SDAI | 47 | 39.18 | 23.50 | 18.00 | 19.50 | 0.0001 |
CRP (μg/ml) | 47 | 18.00 | 43.60 | 7.00 | 14.60 | 0.0002 |
ACPA (IU/ml) | 40 | 331.90 | 1006.60 | 185.60 | 654.15 | 0.0032 |
IL-4 (pg/ml) | 10 | 2.55 | 7.99 | 5.24 | 7.18 | NS |
IL-8 (pg/ml) | 44 | 7.68 | 14.15 | 5.23 | 5.98 | NS |
IL-10 (pg/ml) | 10 | 7.34 | 27.79 | 19.18 | 19.91 | NS |
G-CSF (pg/ml) | 44 | 14.42 | 36.94 | 12.18 | 81.23 | NS |
VEGF (pg/ml) | 44 | 130.52 | 512.22 | 92.22 | 148.07 | NS |
Risk allele positive | ||||||
Variable | n | Baseline | 6 months | P value | ||
| Â | Â | Median | IQR | Median | IQR | Â |
SDAI | 68 | 40.04 | 22.12 | 16.00 | 16.52 | 0.0001 |
CRP (μg/ml) | 68 | 17.50 | 38.70 | 10.10 | 17.50 | 0.0005 |
ACPA (IU/ml) | 56 | 561.10 | 911.05 | 277.60 | 677.80 | 0.0001 |
IL-4 (pg/ml) | 19 | 5.00 | 9.80 | 1.00 | 1.50 | 0.0007 |
IL-8 (pg/ml) | 65 | 9.49 | 12.15 | 5.97 | 6.20 | 0.0001 |
IL-10 (pg/ml) | 19 | 11.24 | 18.78 | 5.53 | 6.52 | 0.0440 |
G-CSF (pg/ml) | 65 | 8.66 | 42.11 | 1.85 | 24.74 | 0.0442 |
VEGF (pg/ml) | 65 | 190.43 | 401.81 | 95.76 | 160.99 | 0.0056 |