From: Comparison of various SYSADOA for the osteoarthritis treatment: an experimental study in rabbits
CARTILAGE | |
Severity of cartilage pathology | |
Normal volume, smooth Surface, intact | 0 |
Surface undulations. Superficial zone fissures | 1 |
Middle zone fissures and/or superficial erosions | 2 |
Deep zone fissures and/or erosion through mid zone | 3 |
Full thickness loss of cartilage | 4 |
Severity of chondrocyte pathology | |
Normal | 0 |
Loos of superficial cells or relative increased density with occasional clusters | 1 |
Small clusters (2–4 cells) predominate | 2 |
Large clusters (up to 5 cells) predominate | 3 |
Cell loss (necrosis/apoptosis) predominate | 4 |
Severity of proteoglycan pathology | |
Normal | 0 |
Decreased proteoglycan in the superficial zone | 1 |
Decreased proteoglycan into the mid zone | 2 |
Decreased proteoglycan into the deep zone | 3 |
Full depth | 4 |
Tidemark | |
Intact and distinct | 0 |
Loss and/or duplication but distinct | 1 |
Loss. Crossed by blood vessels | 2 |
SYNOVIAL MEMBRANE | |
Lining cell characteristics | |
1-2 layers of cells | 0 |
3-6 layers of cells | 1 |
˃6 layers of cells | 2 |
Hyperplasia | |
No hyperplasia | 0 |
Short villi | 1 |
Finger-like hyperplasia | 2 |
Cell infiltration characteristics | |
No cellular infiltration | 0 |
Mid to moderate inflammatory infiltration. Including small lymphoid follicles | 1 |
Marked and diffuse inflammatory infiltration. Large lymphoid follicles. | 2 |