Comparison of plasma levels of (A) AGEs and (B) soluble RAGE (sRAGE) among AOSD patients with different patterns of disease courses, including 12 patients with monocyclic pattern, 28 patients with polycyclic pattern, and 12 patients with chronic arthritis. The horizontal line indicates median value for each group. *p < 0.05, **p < 0.005, was determined by Mann–Whitney U test. The changes in (C) plasma levels of AGEs as well as sRAGE and (D) disease activity parameters including clinical activity scores and C-reactive protein (CRP) levels in 16 AOSD patients after 6 months of treatment. Rx.: treatment. Data are presented as mean ± SEM. *p < 0.005, versus before treatment, determined by the Wilcoxon signed rank test.