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Table 4 Meta-analysis of ERα Xba I and Pvu II polymorphisms and OA susceptibility

From: Association between polymorphisms in the estrogen receptor alpha gene and osteoarthritis susceptibility: a meta-analysis

Polymorphism comparison Population OA site No. of studies Test of association Test of heterogeneity Test of publication bias
Begg's test Egger's test
OR 95% CI p-value Model Q test p-value I 2 Z test p-value T test p-value
XbaI (G vs. A) Overall 10 0.87 0.73—1.04 0.13 Random 29.71 0.0005 70% −0.80 0.42 −1.29 0.23
  European 3 0.91 0.82—1.01 0.08 Fixed 1.67 0.43 0%     
  Asian 7 0.80 0.57—1.13 0.21 Random 27.74 0.0001 78%     
AA vs. AG + GG Overall 10 1.16 0.94—1.44 0.17 Random 25.55 0.002 65% 1.16 0.25 0.94 0.38
  European 3 1.17 1.02—1.34 0.03 Fixed 1.91 0.39 0%     
  Asian 7 1.22 0.84—1.79 0.30 Random 21.69 0.001 72%     
AG vs. AA + GG Overall 10 0.93 0.84—1.04 0.22 Fixed 10.61 0.30 15% 0.09 0.93 0.47 0.65
  European 3 0.86 0.75—0.99 0.04 Fixed 1.52 0.47 0%     
  Asian 7 1.06 0.89—1.26 0.52 Fixed 5.87 0.44 0%     
GG vs. AG + AA Overall 10 0.88 0.67—1.17 0.38 Random 14.23 0.11 37% −0.80 0.42 1.89 0.10
  European 3 0.97 0.79—1.20 0.81 Fixed 0.85 0.65 0%     
  Asian 7 0.65 0.36—1.19 0.17 Random 12.58 0.05 52%     
PvuII (C vs. T) Overall 17 0.98 0.93—1.03 0.37 Fixed 19.58 0.24 18% 0.66 0.51 0.87 0.40
  European 10 0.97 0.90—1.04 0.14 Random 13.61 0.14 34%     
  Asian 7 1.07 0.95—1.21 0.25 Fixed 3.19 0.78 0%     
CC vs. TT + CT Overall 17 0.97 0.89—1.06 0.55 Fixed 13.09 0.67 0% 0.08 0.93 0.26 0.80
  European 10 0.94 0.85—1.04 0.21 Fixed 5.05 0.83 0%     
  Asian 7 1.17 0.94—1.47 0.16 Fixed 4.94 0.55 0%     
CT vs. CC + TT Overall 17 0.99 0.92—1.06 0.75 Fixed 19.85 0.23 19% 0.41 0.68 0.73 0.48
  European 10 1.01 0.91—1.13 0.82 Random 15.43 0.08 42%     
  Asian 7 0.96 0.81—1.14 0.64 Fixed 4.29 0.64 0%     
TT vs. CC + CT Overall 17 1.01 0.92—1.12 0.79 Random 23.83 0.09 33% −0.25 0.81 −1.15 0.27
  European 10 1.02 0.90—1.17 0.74 Random 20.33 0.02 56%     
  Asian 7 0.95 0.80—1.13 0.57 Fixed 2.35 0.88 0%