Table 4 Meta-analysis of ERα Xba I and Pvu II polymorphisms and OA susceptibility
Polymorphism comparison | Population OA site | No. of studies | Test of association | Test of heterogeneity | Test of publication bias | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Begg's test | Egger's test | ||||||||||||
OR | 95% CI | p-value | Model | Q test | p-value | I 2 | Z test | p-value | T test | p-value | |||
XbaI (G vs. A) | Overall | 10 | 0.87 | 0.73—1.04 | 0.13 | Random | 29.71 | 0.0005 | 70% | −0.80 | 0.42 | −1.29 | 0.23 |
|  | European | 3 | 0.91 | 0.82—1.01 | 0.08 | Fixed | 1.67 | 0.43 | 0% |  |  |  |  |
|  | Asian | 7 | 0.80 | 0.57—1.13 | 0.21 | Random | 27.74 | 0.0001 | 78% |  |  |  |  |
AA vs. AG + GG | Overall | 10 | 1.16 | 0.94—1.44 | 0.17 | Random | 25.55 | 0.002 | 65% | 1.16 | 0.25 | 0.94 | 0.38 |
|  | European | 3 | 1.17 | 1.02—1.34 | 0.03 | Fixed | 1.91 | 0.39 | 0% |  |  |  |  |
|  | Asian | 7 | 1.22 | 0.84—1.79 | 0.30 | Random | 21.69 | 0.001 | 72% |  |  |  |  |
AG vs. AA + GG | Overall | 10 | 0.93 | 0.84—1.04 | 0.22 | Fixed | 10.61 | 0.30 | 15% | 0.09 | 0.93 | 0.47 | 0.65 |
|  | European | 3 | 0.86 | 0.75—0.99 | 0.04 | Fixed | 1.52 | 0.47 | 0% |  |  |  |  |
|  | Asian | 7 | 1.06 | 0.89—1.26 | 0.52 | Fixed | 5.87 | 0.44 | 0% |  |  |  |  |
GG vs. AG + AA | Overall | 10 | 0.88 | 0.67—1.17 | 0.38 | Random | 14.23 | 0.11 | 37% | −0.80 | 0.42 | 1.89 | 0.10 |
|  | European | 3 | 0.97 | 0.79—1.20 | 0.81 | Fixed | 0.85 | 0.65 | 0% |  |  |  |  |
|  | Asian | 7 | 0.65 | 0.36—1.19 | 0.17 | Random | 12.58 | 0.05 | 52% |  |  |  |  |
PvuII (C vs. T) | Overall | 17 | 0.98 | 0.93—1.03 | 0.37 | Fixed | 19.58 | 0.24 | 18% | 0.66 | 0.51 | 0.87 | 0.40 |
|  | European | 10 | 0.97 | 0.90—1.04 | 0.14 | Random | 13.61 | 0.14 | 34% |  |  |  |  |
|  | Asian | 7 | 1.07 | 0.95—1.21 | 0.25 | Fixed | 3.19 | 0.78 | 0% |  |  |  |  |
CC vs. TT + CT | Overall | 17 | 0.97 | 0.89—1.06 | 0.55 | Fixed | 13.09 | 0.67 | 0% | 0.08 | 0.93 | 0.26 | 0.80 |
|  | European | 10 | 0.94 | 0.85—1.04 | 0.21 | Fixed | 5.05 | 0.83 | 0% |  |  |  |  |
|  | Asian | 7 | 1.17 | 0.94—1.47 | 0.16 | Fixed | 4.94 | 0.55 | 0% |  |  |  |  |
CT vs. CC + TT | Overall | 17 | 0.99 | 0.92—1.06 | 0.75 | Fixed | 19.85 | 0.23 | 19% | 0.41 | 0.68 | 0.73 | 0.48 |
|  | European | 10 | 1.01 | 0.91—1.13 | 0.82 | Random | 15.43 | 0.08 | 42% |  |  |  |  |
|  | Asian | 7 | 0.96 | 0.81—1.14 | 0.64 | Fixed | 4.29 | 0.64 | 0% |  |  |  |  |
TT vs. CC + CT | Overall | 17 | 1.01 | 0.92—1.12 | 0.79 | Random | 23.83 | 0.09 | 33% | −0.25 | 0.81 | −1.15 | 0.27 |
|  | European | 10 | 1.02 | 0.90—1.17 | 0.74 | Random | 20.33 | 0.02 | 56% |  |  |  |  |
|  | Asian | 7 | 0.95 | 0.80—1.13 | 0.57 | Fixed | 2.35 | 0.88 | 0% |  |  |  |  |