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Table 1 Characteristics of the included studies

From: Association between polymorphisms in the estrogen receptor alpha gene and osteoarthritis susceptibility: a meta-analysis

Study [Ref.] Year Country (City) Study design Genotyping Numbers Gender (M/F) Age Polymorphism (s) Quality score
OA Control OA Control OA Control   
Toshio Ushiyama et al. [24] 1998 Japan Case–control PCR 65 318 0/65 0/318 68.5 (49–86) 49-86 XbaI, PvuII 7 (2/2/3)
John Loughlin et al. [29] 2000 UK (Oxford) Case–control PCR 371 369 155/216 221/148 73 (56–90) 73 (59–89) XbaI, PvuII 8 (3/2/3)
Barton L. Wise et al. [30] 2009 USA Cohort PCR 307 214 258/263 61 ± 9 XbaI 8 (4/2/2)
Barton L. Wise et al. [30] 2009 USA Cohort PCR 304 211 253/262 61 ± 9 PvuII
V. M. Borgonio-Cuadra et al. [32] 2012 Mexico Case–control PCR 115 117 23/92 20/97 57.4 ± 9.2 51.8 ± 8.9 XbaI, PvuII 9 (4/2/3)
J. A. Riancho et al. [33] 2010 Spain (Santander) Case–control PCR 272 802 95/177 285/517 72 ± 7 71 ± 10 PvuII 8 (3/2/3)
J. A. Riancho et al. [33] 2010 Spain (Santiago) Case–control PCR 254 473 47/207 295/178 68 ± 6 68 ± 9 PvuII
J. A. Riancho et al. [33] 2010 UK (Oxford) Case–control PCR 445 862 176/269 471/391 64 ± 5 69 ± 7 PvuII
J. A. Riancho et al. [33] 2010 Spain (Santander) Case–control PCR 359 802 180/179 285/517 71 ± 7 71 ± 10 PvuII
J. A. Riancho et al. [33] 2010 Spain (Coruña) Case–control PCR 252 244 90/162 97/147 67 ± 14 65 ± 13 PvuII
J. A. Riancho et al. [33] 2010 Spain (Santiago) Case–control PCR 287 473 110/177 295/178 68 ± 5 68 ± 9 PvuII
J. A. Riancho et al. [33] 2010 UK (Oxford) Case–control PCR 1278 862 503/775 471/391 65 ± 6 69 ± 7 PvuII
K. Lian M.D. et al. [31] 2007 USA Cohort PCR 569 4134 0/569 0/4134 79.6 ± 5.0 78.4 ± 4.6 XbaI, PvuII 8 (4/2/2)
Sheng-Yu Jin et al. [25] 2004 Korea Case–control PCR 151 397 53/98 190/207 58.8 ± 9.6 / XbaI, PvuII 8 (3/2/3)
Zhi Tian et al. [28] 2009 China Case–control PCR 38 40 0/38 0/40 59.2 ± 3.2 58.5 ± 8.6 XbaI, PvuII 7 (2/2/3)
Jiexiang Yang et al. [34] 2009 China Case–control PCR 41 40 31/50 54.6 (28–82) XbaI, PvuII 6 (2/1/3)
Yan Xue et al. [27] 2004 China Case–control PCR 55 176 0/55 0/176 58.7 ± 2.4 60 ± 10 XbaI, PvuII 7 (3/1/3)
Xiaoyu Dai et al. [26] 2014 China Case–control PCR 469 522 113/356 398/124 57.3 ± 10.9 56.4 ± 9.8 XbaI, PvuII 7 (3/1/3)