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Table 3 Recommendations taking into account the balance of benefit (pain reduction and function improvement) and harm (adverse event)

From: Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system

Product Grade of recommendation Quality evidence Balance benefit to harm
Avocado/soybean unsaponifiables Strong Moderate Avocado/soybean unsaponifiables advantageous
Chondroitin sulfate Strong Moderate Chondroitin sulfate advantageous
Diacereine Strong Moderate Diacereine advantageous
Glucosamine sulfate Strong Moderate Glucosamine sulfate advantageous
Hyaluronic acid Strong Moderate Hyaluronic acid advantageous
Oral calcitonin Weak Low Calcitonin not advantageous
Risedronate Strong High Risedronate not advantageous
Strontium ranelate Weak Very low Strontium ranelate advantageous